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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제17권 제7호
- 발행연도
- 2007.1
- 수록면
- 1,120 - 1,126 (7page)
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초록· 키워드
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This study was performed to screen probioticbifidobacteria for their ability to bind and neutralizelipopolysacharides (LPS) from Escherichia coli and toverify the relationship between LPS-binding ability, celsurface hydrophobicity (CSH), and inhibition of LPS-inducedinterleukin-8 (IL-8) secretion by HT-29 cells of the variousbifidobacterial strains. Ninety bifidobacteria isolates fromhuman feces were asesed for their ability to bind fluoresceinisothiocyanate (FITC)-labeled LPS from E. coli. Isolatesshowing 30-60% binding were designated LPS-high binding(LPS-H) and those with less than 15% binding were designatedLPS-low binding (LPS-L). The CSH, autoaggregation (AA),of the LPS-H and LPS-L groups were evaluated. Fivebifidobacteria strains showed high levels of LPS binding,CSH, AA, and inhibition of IL-8 release. However, statisticallysignificant correlations betwen LPS binding, CSH, AA, andreduction of IL-8 release were not found. Although we couldisolate bifidobacteria with high LPS-binding ability, CSH,A, and inhibition of IL-8 release, each characteristic shouldbe considered as strain dependent. Bifidobacteria with highLPS binding and inhibition of IL-8 release may be goodagents for preventing inflammation by neutralizing Gram-negative endotoxins and improving intestinal health.
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참고문헌 (27)
참고문헌 신청
Alander. M / 1997 / and A. Wright. 1997. Recovery of Lactobacillus rhRecovery of Lactobacillus rhamnosus GG from human colonic biopsiesamnosus GG from human colonic biopsies.
Bibiloni, R / 2005 / VSL#3 probiotic mixture induces remission in patients with active ulcerative colitis 100 : 1539 ~ 1546
Boris, S / 1997 / Characterization of the aggregation promoting factor from Lactobacillus gasseri, a vaginal isolate 83 : 413 ~ 420
Cario, E. / 2000 / Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease 68 : 7010 ~ 7017
De Dooy, J. J / 2001 / The role of inflammation in the development of chronic lung disease in neonates 160 : 457 ~ 463
Bibiloni, R / 2005 / VSL#3 probiotic mixture induces remission in patients with active ulcerative colitis 100 : 1539 ~ 1546
Boris, S / 1997 / Characterization of the aggregation promoting factor from Lactobacillus gasseri, a vaginal isolate 83 : 413 ~ 420
Cario, E. / 2000 / Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease 68 : 7010 ~ 7017
De Dooy, J. J / 2001 / The role of inflammation in the development of chronic lung disease in neonates 160 : 457 ~ 463
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