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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제1호
- 발행연도
- 2008.1
- 수록면
- 95 - 103 (9page)
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Mushrooms are regarded as one of the well-known foods and biopharmaceutical materials with a great deal of interest. Polysaccharide β-glucan is the major component of mushrooms that displays various biological activities such as antidiabetic, anticancer, and antihyperlipidemic effects. In this study, we compared the immunostimulatory potency of polysaccharide fractions, prepared from liquid culture of pine-mushroom Tricholoma matsutake, with a potent immunogen lipopolysaccharide (LPS), and their molecular mechanisms on the functional activation of macrophages. We found that fraction II (TMF-II) was able to comparably upregulate or highly enhance the phenotypic functions of macrophages such NO production and cytokine (IL-1β, IL-6, IL-12, and TNF-α) expression, to LPS. TMF-II triggered the phosphorylation of IκBα, a critical step for NF-κB activation and translocation. Of the upstream signaling enzymes tested, Src and Akt were thought to be the responsible upstream signaling components in induction of NO production, although TMF-II strongly upregulated the phosphorylation of all MAPK pathways.
Therefore, our data suggest that T. matsutake-derived β- glucan may exert its immunostimulating activities with similar potency to LPS via activation of multiple signaling pathways linked to NF-κB activation.
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참고문헌 (22)
참고문헌 신청
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Allavena, P. / 2004 / From pattern recognition receptor to regulator of homeostasis: The double-faced macrophage mannose receptor. Crit. Rev / Immunol 24 : 179 ~ 192
Borchers, A. T. / 1999 / Mushrooms, tumors, and immunity. Proc. Soc. Exp. Biol / Med 221 : 281 ~ 293
Brown, G. D. / 2006 / Dectin-1: A signalling non-TLR patternrecognition receptor. Nat. Rev / Immunol 6 : 33 ~ 43
CHO, HYUN-JEONG / 2007 / Inhibitory Effects of Cordycepin (3'-Deoxyadenosine), a Component ofCordyceps militaris, on Human Platelet Aggregation Induced by Thapsigargin / Jour
Allavena, P. / 2004 / From pattern recognition receptor to regulator of homeostasis: The double-faced macrophage mannose receptor. Crit. Rev / Immunol 24 : 179 ~ 192
Borchers, A. T. / 1999 / Mushrooms, tumors, and immunity. Proc. Soc. Exp. Biol / Med 221 : 281 ~ 293
Brown, G. D. / 2006 / Dectin-1: A signalling non-TLR patternrecognition receptor. Nat. Rev / Immunol 6 : 33 ~ 43
CHO, HYUN-JEONG / 2007 / Inhibitory Effects of Cordycepin (3'-Deoxyadenosine), a Component ofCordyceps militaris, on Human Platelet Aggregation Induced by Thapsigargin / Jour
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Journal of Microbiology and Biotechnology
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Analysis of Bacterial Diversity and Communities Associated with Tricholoma matsutake Fruiting Bodies by Barcoded Pyrosequencing in Sichuan Province, Southwest China
Journal of Microbiology and Biotechnology
2016 .01
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송이(Tricholoma matsutake)의 자실체에서 추출한 조다당류가 생쥐의 Sarcoma 180에 미치는 항암 및 면역증강 작용
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