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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제5호
- 발행연도
- 2009.1
- 수록면
- 530 - 536 (7page)
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Cobalt chloride (CoCl2) treatment of cells in vitro has
been shown to induce cellular changes that are similar to
those seen following hypoxia. To identify genes that are
differentially expressed in response to treatment with
CoCl2, we compared the mRNA expression profiles of PC-3
cells that were treated with CoCl2 with those of untreated
PC-3 cells, using specific arbitrary primers and two
anchored oligo(dT) primers provided in the ACP-based
GeneFishing kits. The results of this study demonstrated
that the puromycin-sensitive aminopeptidase (PSA) gene
was downregulated in PC-3 cells that were treated with
CoCl2. This downregulation of PSA expression, in turn,
suppressed the proliferation, migration, and invasion of
PC-3 cells, as well as the secretion and expression of
matrix metalloproteinase-9 (MMP-9).
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참고문헌 (27)
참고문헌 신청
Akada, T. / 2002 / Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is involved in the activation of endothelial integrins / J. Cell Physiol 193 : 253 ~ 262
Bergers, G. / 2003 / Tumorigenesis and the angiogenic switch / Nat. Rev. Cancer 3 : 401 ~ 410
Bhagwat, S. V. / 2001 / CD13/APN is activated by angiogenic signals and is essential for capillary tube formation / Blood 97 : 652 ~ 659
Brahimi-Horn, C. / 2001 / Hypoxia: The tumor’s gateway to progression along the angiogenic pathway / Trends Cell Biol 11 : S32 ~ S36
Bunn, H. F. / 1996 / Oxygen sensing and molecular adaptation to hypoxia / Physiol. Rev 76 : 839 ~ 885
Bergers, G. / 2003 / Tumorigenesis and the angiogenic switch / Nat. Rev. Cancer 3 : 401 ~ 410
Bhagwat, S. V. / 2001 / CD13/APN is activated by angiogenic signals and is essential for capillary tube formation / Blood 97 : 652 ~ 659
Brahimi-Horn, C. / 2001 / Hypoxia: The tumor’s gateway to progression along the angiogenic pathway / Trends Cell Biol 11 : S32 ~ S36
Bunn, H. F. / 1996 / Oxygen sensing and molecular adaptation to hypoxia / Physiol. Rev 76 : 839 ~ 885
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