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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제9호
- 발행연도
- 2010.1
- 수록면
- 1,295 - 1,299 (5page)
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Recently, recombinant Streptomyces venezuelae has been established as a heterologous host for microbial production of flavanones and stilbenes, a class of plant-specific polyketides. In the present work, we expanded the applicability of the S. venezuelae system to the production of more diverse plant polyketides including flavones and flavonols.
A plasmid with the synthetic codon-optimized flavone synthase I gene from Petroselium crispum was introduced to S. venezuelae DHS2001 bearing a deletion of the native pikromycin polyketide synthase gene, and the resulting strain generated flavones from exogenously fed flavanones.
In addition, a recombinant S. venezuelae mutant expressing a codon-optimized flavanone 3β-hydroxylase gene from Citrus siensis and a flavonol synthase gene from Citrus unshius also successfully produced flavonols.
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참고문헌 (13)
참고문헌 신청
Harborne, J. B / 1992 / Advances in flavonoid research since 1992 / Phytochemistry 55 : 481 ~ 504
Hoover, D. M / 2002 / DNAWorks: An automated method for designing oligonucleotides for PCRbased gene synthesis / Nucleic Acids Res 30 : e43 ~
Jung, W. S / 2006 / Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae / Appl. Microbiol. Biotec
Kieser, T. M / 2000 / Practical Streptomyces Genetics / John Innes Foundation
Kim, B. G / 2006 / Regiospecific flavonoid 7-O-methylation with Streptomyces avermitilis O-methyltransferase expressed in Escherichia coli / J. Agric. Food Chem 54 : 823 ~ 82
Hoover, D. M / 2002 / DNAWorks: An automated method for designing oligonucleotides for PCRbased gene synthesis / Nucleic Acids Res 30 : e43 ~
Jung, W. S / 2006 / Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae / Appl. Microbiol. Biotec
Kieser, T. M / 2000 / Practical Streptomyces Genetics / John Innes Foundation
Kim, B. G / 2006 / Regiospecific flavonoid 7-O-methylation with Streptomyces avermitilis O-methyltransferase expressed in Escherichia coli / J. Agric. Food Chem 54 : 823 ~ 82
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