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The term polyketide defines a class of natural products synthesized through the successive condensation of small carboxylic acids, which results in products containing multiple carbonyl or hydroxyl groups, each separated by one carbon atom, as in the structural element CH2C(=O)CH2CH(OH)CH2C(=O)-. Plant flavonoids, fungal aflatoxins, as well as hundreds of compounds of different structures that can inhibit the growth of bacteria, viruses, fungi, parasites or human tumor cells are included in this diverse group. Some of antifungal polyketides also have immunosuppresive activity. Polyketides can vary widely in structure, and the diversity of polyketide structures reflects the wide variety of their biological properties. This review focuses on the biosynthesis of polyketides and recent progress in combinatorial biosynthesis of new hybrid polyketide compounds.
목차
Abstract
서 론
Fungal polyketide synthase (methylsalicylic acid synthase, MSAS)
Bacterial polyketide synthase
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UCI(KEPA) : I410-ECN-0101-2016-470-002791603