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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제5호
- 발행연도
- 2016.1
- 수록면
- 967 - 974 (8page)
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초록· 키워드
오류제보하기
Zearalenone (ZEA) is an estrogenic mycotoxin that is produced by several Fusarium species, including Fusarium graminearum. One of the ZEA biosynthetic genes, ZEB2, encodes two isoforms of Zeb2 by alternative transcription, forming an activator (Zeb2L-Zeb2L homooligomer) and an inhibitor (Zeb2L-Zeb2S heterodimer) that directly regulate the ZEA biosynthetic genes in F. graminearum. Cyclic AMP-dependent protein kinase A (PKA) signaling regulates secondary metabolic processes in several filamentous fungi. In this study, we investigated the effects of the PKA signaling pathway on ZEA biosynthesis. Through functional analyses of PKA catalytic and regulatory subunits (CPKs and PKR), we found that the PKA pathway negatively regulates ZEA production. Genetic and biochemical evidence further demonstrated that the PKA pathway specifically represses ZEB2L transcription and also takes part in posttranscriptional regulation of ZEB2L during ZEA production. Our findings reveal the intriguing mechanism that the PKA pathway regulates secondary metabolite production by reprograming alternative transcription.
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참고문헌 (33)
참고문헌 신청
Banno S / 2005 / A catalytic sub unit o f cyclic AMPdependent protein kinase, PKAC-1, regulates asexual differentiation in Neurospora crassa / Genes Genet. Syst 80:25~34
Bowden RL / 1999 / Sexual recombination in Gibberella zeae / Phytopathology 89:182~188
Casperson GF / 1985 / Isolation of the gene encoding adenylate cyclase in Saccharomyces cerevisiae / Proc. Natl. Acad. Sci. USA 82:5060~5063
Choi W / 1997 / The adenylate cyclase gene MAC1of Magnaporthe grisea controls appressorium formation and other aspects of growth and development / Plant Cell 9:1973~1983
Dürrenberger F / 1998 / Identification of a cAMP-dependent protein kinase catalytic subunit required for virulence and morphogenesis in Ustilago maydis / Proc. Natl. Acad. Sci. USA 95:5684~5689
Bowden RL / 1999 / Sexual recombination in Gibberella zeae / Phytopathology 89:182~188
Casperson GF / 1985 / Isolation of the gene encoding adenylate cyclase in Saccharomyces cerevisiae / Proc. Natl. Acad. Sci. USA 82:5060~5063
Choi W / 1997 / The adenylate cyclase gene MAC1of Magnaporthe grisea controls appressorium formation and other aspects of growth and development / Plant Cell 9:1973~1983
Dürrenberger F / 1998 / Identification of a cAMP-dependent protein kinase catalytic subunit required for virulence and morphogenesis in Ustilago maydis / Proc. Natl. Acad. Sci. USA 95:5684~5689
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