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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제10호
- 발행연도
- 2006.1
- 수록면
- 1,491 - 1,498 (8page)
이용수
초록· 키워드
오류제보하기
The feasibility of pullulan acetate nanoparticles(PAN) with ionic strength (IS) sensitivity as a radioisotopecarrier to inhibit tumor growth is demonstrated. PAN wasradiolabeled with rhenium 18 (Re-188) without any chelatingagents. The labeling efficiency of Re-188 into PAN (Re-18-PAN) was 49.3±4.0% as determined by TLC. The tumorvolumes of mice treated with 0.45 mCi of Re-188-PAN weremeasured and compared with that of free Re-188 after 5days of intratumoral injection. For the histological evaluation(H&E), and terminal deoxynucleotidyl transferase biotinylateddeoxyuridine triphosphate nick end labeling (TUNEL)staining were performed. The mean tumor volume of theRe-188-PAN-treated group was decreased by 36% after 5 days,whereas that the fre Re-188-treated group was decreasedby only 15% (P<0.05). The mean number of TUNEL-positive cells in Re-188-PAN-treated tumors at 144.3±79.9cells/section was significantly greater than the control(26.7±7.9 cells/section, P=0.03). The numbers of leukocyteand lymphocyte were decreased in both free Re-188- andRe-188-PAN-treated mice. These results indicated that thethe tumor growth by prolonging Re-188 retention time intumor site induced by the IS sensitivity.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Blower, P. J / 1998 / Pentavalent rhenium-188 dimercaptosuccinic acid for targeted radiotherapy: Synthesis and preliminary animal and human studies / Eur. J. Nucl. Med. 25 :
Cammas, S / 1997 / Thermo-responsive polymer nanoparticles with a core-shell micelle structure as site specific drug carriers / J. Control. Release 48 : 157 ~ 164
Chung, J. E / 2000 / Inner core segment design for delivery control of thermo-responsive polymeric micelles / J. Control. Release 65 : 93 ~ 103
Crudo, J. L / 2002 / Optimization of antibody labeling with rhenium-188 using a prelabeled MAG3 chelate / Int. J. Pharm. 248 : 173 ~ 182
Deutsch, E / 1986 / The chemistry of rhenium and technetium as related to use of isotope of these elements in therapeutic and diagnostic nuclear medicine / Int. J. Radiat. Ap
Cammas, S / 1997 / Thermo-responsive polymer nanoparticles with a core-shell micelle structure as site specific drug carriers / J. Control. Release 48 : 157 ~ 164
Chung, J. E / 2000 / Inner core segment design for delivery control of thermo-responsive polymeric micelles / J. Control. Release 65 : 93 ~ 103
Crudo, J. L / 2002 / Optimization of antibody labeling with rhenium-188 using a prelabeled MAG3 chelate / Int. J. Pharm. 248 : 173 ~ 182
Deutsch, E / 1986 / The chemistry of rhenium and technetium as related to use of isotope of these elements in therapeutic and diagnostic nuclear medicine / Int. J. Radiat. Ap
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