지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제1호
- 발행연도
- 2009.1
- 수록면
- 55 - 64 (10page)
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초록· 키워드
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A B cell-specific growth substance (BGS) was isolated
from the slime layer of Bacillus licheniformis E1. Unlike
LPS, the BGS was not affected by polymixin B, an
inhibitor of LPS, or by TLR4, and resulted in the growth
of B cells. When BALB/c mice were treated with the BGS,
the B cell population was found to increase in both the
bone marrow and the spleen, with a marked increase after
24 h in the bone marrow and after 48 h in the spleen.
When using antibodies to B cell lineage-restricted surface
molecules to analyze the B cell population changes resulting
from treatment with the BGS, an increase in immature B
cells (IgM+ and AA4.1+) and mature B cells (IgM+ and
IgD+) was found in the bone marrow 24 h after treatment
with the BGS, whereas a decrease in mature B cells and
increase in IgG+ B cells were found in the spleen. When the
BGS and OVA antigen were injected into the peritoneal
cavity of BALB/c mice, this resulted in a high OVAspecific
antibody titer in the sera, similar to that induced
by aluminum hydroxide. Therefore, it is anticipated that
the mass production of the BGS by B. licheniformis E1
could be used for studies of B cells in immunology, and
contribute to the development of a new adjuvant for
vaccine manufacture.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)]
Abbas, A. K. / 2007 / Cellular and Molecular Immunology / Saunders Elsevier
Ahmed, R. / 1996 / Immunological memory and protective immunity: Understanding their relation / Science 272 : 54 ~ 60
Allman, D. M. / 1992 / Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics / J. Immu
Allman, D. M. / 1993 / Peripheral B cell maturation. II. Heat-stable antigen (hi) splenic B cells are an immature developmental intermediate in the production of long-lived m
Abbas, A. K. / 2007 / Cellular and Molecular Immunology / Saunders Elsevier
Ahmed, R. / 1996 / Immunological memory and protective immunity: Understanding their relation / Science 272 : 54 ~ 60
Allman, D. M. / 1992 / Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics / J. Immu
Allman, D. M. / 1993 / Peripheral B cell maturation. II. Heat-stable antigen (hi) splenic B cells are an immature developmental intermediate in the production of long-lived m
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