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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제3호
- 발행연도
- 2016.1
- 수록면
- 618 - 626 (9page)
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초록· 키워드
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Pleural effusion lymphoma (PEL) is a rare B-cell lymphoma that has a very poor prognosis with a median survival time of around 6 months. PEL is caused by Kaposi’s sarcomaassociated herpesvirus, and is often co-infected with the Epstein Barr virus. The complement system is fundamental in the innate immune system against pathogen invasion and tumor development. In the present study, we investigated the activation of the complement system in PEL cells using human serum complements. Interestingly, two widely used PEL cell lines, BCP-1 and BCBL-1, showed different susceptibility to the complement system, which may be due to CD46 expression on their cell membranes. Complement activation did not induce apoptosis but supported cell survival considerably. Our results demonstrated the susceptibility of PEL to the complement system and its underlying mechanisms, which would provide insight into understanding the pathogenesis of PEL.
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참고문헌 (29)
참고문헌 신청
Budzko DB / 1976 / Activation of the alternative complement pathway by lymphoblastoid cell lines derived from patients with Burkitt's lymphoma and infectious mononucleosis / Cell. Immunol 22:98~109
Caudwell V / 1990 / Complement alternative pathway activation and control on membranes of human lymphoid B cell lines / Eur. J. Immunol 20:2643~2650
Des Prez RM / 1975 / Function of the classical and alternate pathways of human complement in serum treated with ethylene glycol tetraacetic acid and MgCl2-ethylene glycol tetraacetic acid / Infect. Immun 11:1235~1243
Devaux P / 2004 / Cell surface activation of the alternative complement pathway by the fusion protein of measles virus / J. Gen. Virol 85:1665~1673
Douglas JL / 2010 / Kaposi sarcoma pathogenesis: a triad of viral infection, oncogenesis and chronic inflammation / Transl. Biomed 1:172
Caudwell V / 1990 / Complement alternative pathway activation and control on membranes of human lymphoid B cell lines / Eur. J. Immunol 20:2643~2650
Des Prez RM / 1975 / Function of the classical and alternate pathways of human complement in serum treated with ethylene glycol tetraacetic acid and MgCl2-ethylene glycol tetraacetic acid / Infect. Immun 11:1235~1243
Devaux P / 2004 / Cell surface activation of the alternative complement pathway by the fusion protein of measles virus / J. Gen. Virol 85:1665~1673
Douglas JL / 2010 / Kaposi sarcoma pathogenesis: a triad of viral infection, oncogenesis and chronic inflammation / Transl. Biomed 1:172
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