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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제1호
- 발행연도
- 2017.1
- 수록면
- 189 - 196 (8page)
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Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with formation of Kaposi’s sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. Replication and transcription activator (RTA) genes are expressed upon reactivation of KSHV, which displays a biphasic life cycle consisting of latent and lytic replication phases. RTA protein expression results in KSHV genome amplification and successive viral lytic gene expression. Transcriptional activity of viral lytic genes is regulated through epigenetic modifications. In Raji cells latently infected with Epstein-Barr virus, various modifications, such as acetylation and methylation, have been identified at specific lysine residues in histone H4 during viral reactivation, supporting the theory that expression of specific lytic genes is controlled by histone modification processes. Data obtained from chromatin immunoprecipitation and quantitative real-time PCR analyses revealed alterations in the H4K8ac and H4K20me3 levels at lytic gene promoters during reactivation. Our results indicate that H4K20me3 is associated with the maintenance of latency, while H4K8ac contributes to KSHV reactivation in infected TREx BCBL-1 RTA cells.
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참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] -
Ballestas ME / 1999 / Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen / Science 284 : 641 ~ 644
Bartova E / 2008 / Histone modifications and nuclear architecture: a review / J. Histochem. Cytochem 56 : 711 ~ 721
Berger SL / 2007 / The complex language of chromatin regulation during transcription / Nature 447 : 407 ~ 412
Bernst ein BE / 2007 / The mammalian epigenome / Cell 128 : 669 ~ 681
Ballestas ME / 1999 / Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen / Science 284 : 641 ~ 644
Bartova E / 2008 / Histone modifications and nuclear architecture: a review / J. Histochem. Cytochem 56 : 711 ~ 721
Berger SL / 2007 / The complex language of chromatin regulation during transcription / Nature 447 : 407 ~ 412
Bernst ein BE / 2007 / The mammalian epigenome / Cell 128 : 669 ~ 681
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