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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제2호
- 발행연도
- 2017.1
- 수록면
- 242 - 250 (9page)
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초록· 키워드
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Anti-photoaging effects of standardized Siegesbeckia glabrescens extract (SGE) and its major active compound kirenol were investigated using Hs68 human dermal fibroblasts and hairless mice, respectively. UVB-irradiated hairless mice that received oral SGE (600 mg/kg/day) showed reduced wrinkle formation and skinfold thickness compared with the UVB-irradiated control. Furthermore, SGE treatment increased the mRNA levels of collagen synthesis genes (COL1A1, COL3A1, COL4A1, and COL7A1) and activated antioxidant enzyme (catalase), while suppressing matrix metalloproteinase (MMP-2, -3, -9, and -13) expression. In Hs68 fibroblasts, kirenol also significantly suppressed MMP expression while increasing the expression of COL1A1, COL3A1, and COL7A1. Collectively, our data demonstrate that both SGE and kirenol attenuated UVB-induced photoaging in hairless mice and fibroblasts through inhibition of the mitogen-activated protein kinases and nuclear factor kappa B pathways, suggesting that SGE has potential to serve as a natural anti-photoaging nutraceutical.
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참고문헌 (22)
참고문헌 신청
Afaq F / 2006 / Botanical antioxidants in the prevention of photocarcinogenesis and photoaging / Exp. Dermatol 15 : 678 ~ 684
Bai B / 2015 / Intraperitoneally administered biliverdin protects against UVB-induced skin photo-damage in hairless mice / J. Photochem. Photobiol. B 144 : 35 ~ 41
Cho YR / 2013 / The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signali
Davies KJ / 2014 / The complex interaction of matrix metalloproteinases in the migration of cancer cells through breast tissue stroma / Int. J. Breast Cancer 2014 : 839094 ~
Fujii T / 2013 / Effects of amla extract and collagen peptide on UVBinduced photoaging in hairless mice / J. Funct. Foods 5 : 451 ~ 459
Bai B / 2015 / Intraperitoneally administered biliverdin protects against UVB-induced skin photo-damage in hairless mice / J. Photochem. Photobiol. B 144 : 35 ~ 41
Cho YR / 2013 / The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signali
Davies KJ / 2014 / The complex interaction of matrix metalloproteinases in the migration of cancer cells through breast tissue stroma / Int. J. Breast Cancer 2014 : 839094 ~
Fujii T / 2013 / Effects of amla extract and collagen peptide on UVBinduced photoaging in hairless mice / J. Funct. Foods 5 : 451 ~ 459
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