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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제11호
- 발행연도
- 2018.1
- 수록면
- 1,771 - 1,781 (11page)
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초록· 키워드
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The emergence of multidrug-resistant microorganisms, as well as fungal infectious diseases that further threaten health, especially in immunodeficient populations, is a major global problem. The development of new antifungal agents in clinical trials is inferior to the incidence of drug resistance, and the available antifungal agents are restricted. Their mechanisms aim at certain characteristics of the fungus in order to avoid biological similarities with the host. Synthesis of the cell wall and ergosterol are mainly targeted in clinical use. The need for new approaches to antifungal therapeutic agents or development alternatives has increased. This review explores new perspectives on mechanisms to effectively combat fungal infections and effective antifungal activity. The clinical drug have a common feature that ultimately causes caspase-dependent cell death. The drugs-induced cell death pathway is associated with mitochondrial dysfunction, including mitochondrial membrane depolarization and cytochrome c release. This mechanism of action also reveals antimicrobial peptides, the primary effector molecules of innate systems, to highlight new alternatives. Furthermore, drug combination therapy is suggested as another strategy to combat fungal infection. The proposal for a new approach to antifungal agents is not only important from a basic scientific point of view, but will also assist in the selection of molecules for combination therapy.
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참고문헌 (101)
참고문헌 신청
Campoy S / 2017 / Antifungals / Biochem. Pharmacol 133:86~96
Perfect JR. / 2017 / The antifungal pipeline: a reality check / Nat. Rev. Drug Discov 16:603~616
Liu S / 2014 / Combination of fluconazole with non-antifungal agents: a promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery / Int. J. Antimicrob. Agents 43:395~402
Brown GD / 2012 / Hidden killers: human fungal infections / Sci. Transl. Med 4:165rv113
Shor E / 2015 / A case for two-component signaling systems as antifungal drug targets / PLoS Pathog 11:e1004632
Perfect JR. / 2017 / The antifungal pipeline: a reality check / Nat. Rev. Drug Discov 16:603~616
Liu S / 2014 / Combination of fluconazole with non-antifungal agents: a promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery / Int. J. Antimicrob. Agents 43:395~402
Brown GD / 2012 / Hidden killers: human fungal infections / Sci. Transl. Med 4:165rv113
Shor E / 2015 / A case for two-component signaling systems as antifungal drug targets / PLoS Pathog 11:e1004632
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