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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제7호
- 발행연도
- 2015.1
- 수록면
- 1,026 - 1,035 (10page)
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초록· 키워드
오류제보하기
Condensin is not only responsible for chromosome condensation, but is also involved in double-strand break (DSB) processing in the cell cycle. During meiosis, the condensin complex serves as a component of the meiotic chromosome axis, and mediates both proper assembly of the synaptonemal complex and DSB repair, in order to ensure proper homologous chromosome segregation. Here, we used the budding yeast Saccharomyces cerevisiae to show that condensin participates in a variety of chromosome organization processes and exhibits crucial molecular functions that contribute to meiotic recombination during meiotic prophase I. We demonstrate that Ycs4 is required for efficient DSB formation and establishing homolog bias at the early stage of meiotic prophase I, which allows efficient formation of interhomolog recombination products. In the Ycs4 meiosis-specific allele (ycs4S), interhomolog products were formed at substantial levels, but with the same reduction in crossovers and noncrossovers. We further show that, in prophase chromosomal events, ycs4S relieved the defects in the progression of recombination interactions induced as a result of the absence of Rec8. These results suggest that condensin is a crucial coordinator of the recombination process and chromosome organization during meiosis.
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참고문헌 (26)
참고문헌 신청
Allers T / 2001 / Differential timing and control of noncrossover and crossover recombination during meiosis / Cell 13 : 47 ~ 57
Anderson DE / 2002 / Condensin and cohesin display different arm conformations with characteristic hinge angles / J. Cell Biol 156 : 419 ~ 424
Bhalla N / 2002 / Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior / Mol. Biol. Cell 13 : 632 ~ 645
Brito IL / 2010 / Condensins promote coorientation of sister chromatids during meiosis I in budding yeast / Genetics 185 : 55 ~ 64
Bzymek M / 2010 / Double Holliday junctions are intermediates of DNA break repair / Nature 464 : 937 ~ 941
Anderson DE / 2002 / Condensin and cohesin display different arm conformations with characteristic hinge angles / J. Cell Biol 156 : 419 ~ 424
Bhalla N / 2002 / Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior / Mol. Biol. Cell 13 : 632 ~ 645
Brito IL / 2010 / Condensins promote coorientation of sister chromatids during meiosis I in budding yeast / Genetics 185 : 55 ~ 64
Bzymek M / 2010 / Double Holliday junctions are intermediates of DNA break repair / Nature 464 : 937 ~ 941
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