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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제2호
- 발행연도
- 2017.1
- 수록면
- 405 - 411 (7page)
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초록· 키워드
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Homologous recombination occurs between homologous chromosomes and is significantly involved in programmed double-strand break (DSB) repair. Activation of two recombinases, Rad51 and Dmc1, is essential for an interhomolog bias during meiosis. Rad51 participates in both mitotic and meiotic recombination, and its strand exchange activity is regulated by an inhibitory factor during meiosis. Thus, activities of Rad51 and Dmc1 are coordinated to promote homolog bias. It has been reported that Hed1, a meiosis-specific protein in budding yeast, regulates Rad51-dependent recombination activity. Here, we investigated the role of Hed1 in meiotic recombination by ectopic expression of the protein after pre-meiotic replication in Saccharomyces cerevisiae. DNA physical analysis revealed that the overexpression of Hed1 delays the DSB-to-joint molecule (JM) transition and promotes interhomolog JM formation. The study indicates a possible role of Hed1 in controlling the strand exchange activity of Rad51 and, eventually, meiotic crossover formation.
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참고문헌 (26)
참고문헌 신청
Arora C / 2004 / Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism / Mol. Cell 13 : 54
Bishop DK / 1992 / DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression / Cell 69 :
Bishop DK / 1994 / RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis / Cell 79 : 1081 ~ 1092
Bishop DK / 2004 / Early decision; meiotic crossover interference prior to stable strand exchange and synapsis / Cell 117 : 9 ~ 15
Busygina V / 2008 / Hed1 regulates Rad51-mediated recombination via a novel mec
Bishop DK / 1992 / DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression / Cell 69 :
Bishop DK / 1994 / RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis / Cell 79 : 1081 ~ 1092
Bishop DK / 2004 / Early decision; meiotic crossover interference prior to stable strand exchange and synapsis / Cell 117 : 9 ~ 15
Busygina V / 2008 / Hed1 regulates Rad51-mediated recombination via a novel mec
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