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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제8호
- 발행연도
- 2015.1
- 수록면
- 1,380 - 1,389 (10page)
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초록· 키워드
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Prx1, an AhpF-dependent 2-Cys peroxiredoxin (Prx), was previously identified in Vibrio vulnificus, a facultative aerobic pathogen. In the present study, transcription of the V. vulnificus prx1ahpF genes, which are adjacently located on the chromosome, was evaluated by analyzing the promoter and intergenic region of the two genes. Northern blot analyses revealed that transcription of prx1ahpF results in two transcripts, the prx1 and prx1ahpF transcripts. Primer extension analysis and a point mutational analysis of the promoter region showed that the two transcripts are generated from a single promoter. In addition, the 3’ end of the prx1 transcript at the prx1ahpF intergenic region was determined by a 3’RACE assay. These results suggested that the prx1ahpF genes are transcribed as an operon, and the prx1 transcript was produced by transcriptional termination in the intergenic region. RNA secondary structure prediction of the prx1ahpF intergenic region singled out a stem-loop structure without poly(U) tract, and a deletion analysis of the intergenic region showed that the atypical stem-loop structure acts as the transcriptional attenuator to result in the prx1 and prx1ahpF transcripts. The combined results demonstrate that the differential expression of prx1 and ahpF is accomplished by the cis-acting transcriptional attenuator located between the two genes and thereby leads to the production of a high level of Prx1 and a low level of AhpF.
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참고문헌 (23)
참고문헌 신청
Abe H / 1996 / Differential contributions of two elements of rho-independent terminator to transcription termination and mRNA stabilization / Biochimie 78 : 1035 ~ 1042
Bang YJ / 2012 / Distinct characteristics of two 2-Cys peroxiredoxins of Vibrio vulnificus suggesting differential roles in detoxifying oxidative stress / J. Biol. Chem 287 :
Browning DF / 2004 / The regulation of bacterial transcription initiation / Nat. Rev. Microbiol 2 : 57 ~ 65
Christman MF / 1985 / Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium / Cell 41 : 753 ~ 762
Dubbs JM / 2007 / Peroxiredoxins in bacterial antioxidant defense / Subcell. Biochem 44 : 143 ~ 193
Bang YJ / 2012 / Distinct characteristics of two 2-Cys peroxiredoxins of Vibrio vulnificus suggesting differential roles in detoxifying oxidative stress / J. Biol. Chem 287 :
Browning DF / 2004 / The regulation of bacterial transcription initiation / Nat. Rev. Microbiol 2 : 57 ~ 65
Christman MF / 1985 / Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium / Cell 41 : 753 ~ 762
Dubbs JM / 2007 / Peroxiredoxins in bacterial antioxidant defense / Subcell. Biochem 44 : 143 ~ 193
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