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논문 기본 정보
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- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제2호
- 발행연도
- 2009.1
- 수록면
- 121 - 127 (7page)
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Sequencing analysis of a 5-kb DNA fragment from
Streptomyces venezuelae ATCC 15439 revealed the presence of
one 3.1-kb open reading frame (ORF), designated as afsRsv.
The deduced product of afsR-sv (1,056 aa) was found to
have high homology with the global regulatory protein
AfsR. Homology-based analysis showed that afsR-sv represents
a transcriptional activator belonging to the Streptomyces
antibiotic regulatory protein (SARP) family that includes an Nterminal
SARP domain containing a bacterial transcriptional
activation domain (BTAD), an NB-ARC domain, and a Cterminal
tetratricopeptide repeat domain. Gene expression
analysis by reverse transcriptase PCR (RT-PCR) demonstrated
the activation of transcription of genes belonging to pikromycin
production, when afsR-sv was overexpressed in S. venezuelae.
Heterologous expression of the afsR-sv in different Streptomyces
strains resulted in increased production of the respective
antibiotics, suggesting that afsR-sv is a positive regulator of
antibiotics biosynthesis.
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참고문헌 (22)
참고문헌 신청
[학술지(정
Arias, P. / 1999 / Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding
Bibb, M. / 1996 / 1995 Colworth Prize Lecture. The regulation of antibiotic production in Streptomyces coelicolor A3(2) / Microbiology 142 : 1335 ~ 1344
Bystrykh, L. V. / 1996 / Production of actinorhodin-related ‘‘blue pigments’’ by Streptomyces coelicolor A3(2) / J. Bacteriol 178 : 2238 ~ 2244
Demain, A. L. / 1999 / Pharmaceutically active secondary metabolites of microorganisms / Appl. Microbiol. Biotechnol 52 : 455 ~ 463
Arias, P. / 1999 / Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding
Bibb, M. / 1996 / 1995 Colworth Prize Lecture. The regulation of antibiotic production in Streptomyces coelicolor A3(2) / Microbiology 142 : 1335 ~ 1344
Bystrykh, L. V. / 1996 / Production of actinorhodin-related ‘‘blue pigments’’ by Streptomyces coelicolor A3(2) / J. Bacteriol 178 : 2238 ~ 2244
Demain, A. L. / 1999 / Pharmaceutically active secondary metabolites of microorganisms / Appl. Microbiol. Biotechnol 52 : 455 ~ 463
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