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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제11호
- 발행연도
- 2017.1
- 수록면
- 2,070 - 2,073 (4page)
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초록· 키워드
오류제보하기
We have discovered a novel chemical compound, (E)-3-(furan-2-yl)-N-(4-sulfamoylphenyl) acrylamide, that suppresses the enzymatic activities of SARS coronavirus helicase. To determine the inhibitory effect, ATP hydrolysis and double-stranded DNA unwinding assays were performed in the presence of various concentrations of the compound. Through these assays, we obtained IC50 values of 2.09 ± 0.30 μM (ATP hydrolysis) and 13.2 ± 0.9 μM (DNA unwinding), respectively. Moreover, we found that the compound did not have any significant cytotoxicity when 40 μM of it was used. Our results showed that the compound might be useful to be developed as an inhibitor against SARS coronavirus.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Anand K / 2003 / Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs / Science 300 : 1763 ~ 1767
Borowski P / 2002 / Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy / Antiviral Res 55 : 397 ~ 412
Holmes KV. / 2003 / SARS coronavirus: a new challenge for prevention and therapy / J. Clin. Invest 111 : 1605 ~ 1609
Ivanov KA / 2004 / Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase / J. Virol 78 : 5619 ~ 5632
Jang KJ / 2008 / Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase / Biochem. Biophys. Res. Commun 366 : 738
Borowski P / 2002 / Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy / Antiviral Res 55 : 397 ~ 412
Holmes KV. / 2003 / SARS coronavirus: a new challenge for prevention and therapy / J. Clin. Invest 111 : 1605 ~ 1609
Ivanov KA / 2004 / Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase / J. Virol 78 : 5619 ~ 5632
Jang KJ / 2008 / Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase / Biochem. Biophys. Res. Commun 366 : 738
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