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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제11호
- 발행연도
- 2017.1
- 수록면
- 1,925 - 1,931 (7page)
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초록· 키워드
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Korean red pine (Pinus densiflora) bark extract, PineXol (PX), was investigated for its potential antioxidant and anti-inflammation effects in vitro. It was hypothesized that PX treatment (25- 150 μg/ml) would reduce the lipid synthesis in HepG2 hepatocytes as well as lipid accumulation in 3T3-L1 adipocytes. Hepatocytes’ intracellular triglycerides and cholesterol were decreased in the PX 150 μg/ml treatment group compared with the control (p < 0.05).
Consequently, de novo lipogenic proteins (acetyl-CoA carboxylase 1, stearoyl-CoA desaturase 1, elongase of very long chain fatty acids 6, glycerol-3-phosphate acyltransferase 1, and sterol regulatory element-binding protein 1) were significantly decreased in hepatocytes by PX 150 μg/ml treatment compared with the control (p < 0.05). In differentiated 3T3-L1 adipocytes, the lipid accumulation was significantly attenuated by all PX treatments (p < 0.01). Regulators of adipogenesis, including CCAAT-enhancer-binding proteins alpha, peroxisome proliferatoractivated receptor gamma, and perilipin, were decreased in PX 100 μg/ml treatment compared with the control (p < 0.05). In conclusion, PX might have anti-obesity effects by blocking hepatic lipogenesis and by inhibiting adipogenesis in adipocytes.
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참고문헌 (26)
참고문헌 신청
[학술지(정기간행물
Ahmadian M / 2007 / Triacylglycerol metabolism in adipose tissue / Future Lipidol 2 : 229 ~ 237
Bastien M / 2014 / Overview of epidemiology and contribution of obesity to cardiovascular disease / Prog. Cardiovasc. Dis 56 : 369 ~ 381
Bayeta E / 2000 / Pycnogenol inhibits generation of inflammatory mediators in macrophages / Nutr. Res 20 : 249 ~ 259
Canali R / 2009 / The antiinflammatory pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes / Int. Immunopharmacol 9 : 1145 ~ 1149
Ahmadian M / 2007 / Triacylglycerol metabolism in adipose tissue / Future Lipidol 2 : 229 ~ 237
Bastien M / 2014 / Overview of epidemiology and contribution of obesity to cardiovascular disease / Prog. Cardiovasc. Dis 56 : 369 ~ 381
Bayeta E / 2000 / Pycnogenol inhibits generation of inflammatory mediators in macrophages / Nutr. Res 20 : 249 ~ 259
Canali R / 2009 / The antiinflammatory pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes / Int. Immunopharmacol 9 : 1145 ~ 1149
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