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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제10호
- 발행연도
- 2015.1
- 수록면
- 1,697 - 1,701 (5page)
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초록· 키워드
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The anticancer and anti-inflammatory activities of probiotic Lactococcus lactis NK34 were demonstrated. Treatment of cancer cells such as SK-MES-1, DLD-1, HT-29, LoVo, AGS, and MCF-7 cells with 106 CFU/well of L. lactis NK34 resulted in strong inhibition of proliferation (>77% cytotoxicity, p < 0.05). The anti-inflammatory activity of L. lactis NK34 was also demonstrated in lipopolysaccharide-induced RAW 264.7 cells, where the production of nitric oxide and proinflammatory cytokines (tumor necrosis factor-α, interleukin-18, and cyclooxygenase-2) was reduced. These results suggest that L. lactis NK34 could be used as a probiotic microorganism to inhibit the proliferation of cancer cells and production of proinflammatory cytokines.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Baumgart DC / 2009 / Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease / Clin. Exp.
Chang JH / 2010 / Probiotic characteristics of lactic acid isolated from kimchi / J. Appl. Microbiol 109 : 220 ~ 230
Commane D / 2005 / The potential mechanisms involved in the anti-carcinogenic action of probiotics / Mut. Res 591 : 276 ~ 289
Festen EAM / 2009 / Inflammatory bowel disease and celiac disease: overlaps in the pathology and genetics, and their potential drug targets. Curr. Drug Targets Immune Endocr
Heo WS / 2013 / Effects of dietary probiotic, Lactococcus lactis subsp. lactis I2, supplementation on the growth and immune response of olive flounder (Paralichthys olivaceus
Chang JH / 2010 / Probiotic characteristics of lactic acid isolated from kimchi / J. Appl. Microbiol 109 : 220 ~ 230
Commane D / 2005 / The potential mechanisms involved in the anti-carcinogenic action of probiotics / Mut. Res 591 : 276 ~ 289
Festen EAM / 2009 / Inflammatory bowel disease and celiac disease: overlaps in the pathology and genetics, and their potential drug targets. Curr. Drug Targets Immune Endocr
Heo WS / 2013 / Effects of dietary probiotic, Lactococcus lactis subsp. lactis I2, supplementation on the growth and immune response of olive flounder (Paralichthys olivaceus
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