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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제3호
- 발행연도
- 2018.1
- 수록면
- 367 - 374 (8page)
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초록· 키워드
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RNA interference provides an effective tool for developing antitumor therapies. Cellpenetrating peptides (CPPs) are delivery vectors widely used to efficiently transport smallinterfering RNA (siRNA) to intracellular targets. In this study, we investigated the efficacy of the cancer-specific CPP carrier BR2 to specifically transport siRNA to cancer-target cells. Our results showed that BR2 formed a complex with anti-vascular endothelial growth factor siRNA (siVEGF) that exhibited the appropriate size and surface charge for in vivo treatment. Additionally, the BR2-VEGF siRNA complex exhibited significant serum stability and high levels of gene-silencing effects in vitro. Moreover, the transfection efficiency of the complex into a cancer cell line was higher than that observed in non-cancer cell lines, resulting in downregulated intracellular VEGF levels in HeLa cells and comprehensively improved antitumor efficacy in the absence of significant toxicity. These results indicated that BR2 has significant potential for the safe, efficient, and specific delivery of siRNA for diverse applications.
목차
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참고문헌 (40)
참고문헌 신청
Hannon GJ / 2002 / RNA interference / Nature 418:244~251
Fire A / 1998 / Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans / Nature 391:806~811
Elbashir SM / 2001 / Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells / Nature 411:494~498
Morris KV / 2004 / Small interfering RNA-induced transcriptional gene silencing in human cells / Science 305:1289~1292
Aagaard L / 2007 / RNAi therapeutics: principles, prospects and challenges / Adv. Drug Deliv. Rev. 59:75~86
Fire A / 1998 / Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans / Nature 391:806~811
Elbashir SM / 2001 / Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells / Nature 411:494~498
Morris KV / 2004 / Small interfering RNA-induced transcriptional gene silencing in human cells / Science 305:1289~1292
Aagaard L / 2007 / RNAi therapeutics: principles, prospects and challenges / Adv. Drug Deliv. Rev. 59:75~86
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