지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 495 - 500 (6page)
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초록· 키워드
오류제보하기
Brain cytoplasmic 200 RNA (BC200 RNA), originally identified as a neuron-specific non-coding RNA, is also observed in various cancer cells that originate from non-neural cells. Studies have revealed diverse functions of BC200 RNA in cancer cells. Accordingly, we hypothesized that BC200 RNA might be modified in cancer cells to generate cancerous BC200 RNA responsible for its cancer-specific functions. Here, we report that BC200 RNA sequences are highly heterogeneous in cancer cells by virtue of multiple adenine nucleotide insertions in the internal A-rich region. The insertion of adenine nucleotides enhances BC200 RNA-mediated translation inhibition, possibly by increasing the binding affinity of BC200 RNA for eIF4A (eukaryotic translation initiation factor 4A).
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Baranov, P. V. / 2005 / Transcriptional slippage in bacteria : distribution in sequenced genomes and utilization in IS element gene expression / Genome Biol 6:R25
Booy, E. P. / 2017 / The long non-coding RNA BC200(BCYRN1)is critical for cancer cell survival and proliferation / Mol. Cancer 16:109
Briggs, J. A. / 2015 / Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution / Neuron 88:861~877
Chen, W. / 1997 / Expression of neural BC200 RNA in human tumours / J. Pathol 183:345~351
Eom, T. / 2011 / Dual nature of translational control by regulatory BC RNAs / Mol. Cell. Biol 31:4538~4549
Booy, E. P. / 2017 / The long non-coding RNA BC200(BCYRN1)is critical for cancer cell survival and proliferation / Mol. Cancer 16:109
Briggs, J. A. / 2015 / Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution / Neuron 88:861~877
Chen, W. / 1997 / Expression of neural BC200 RNA in human tumours / J. Pathol 183:345~351
Eom, T. / 2011 / Dual nature of translational control by regulatory BC RNAs / Mol. Cell. Biol 31:4538~4549
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