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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제3호
- 발행연도
- 2018.1
- 수록면
- 391 - 396 (6page)
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초록· 키워드
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It is well known that Korean red ginseng has various biological activities. However, there is little knowledge about the antiviral activity of Korean red ginseng and its ginsenosides. In this study, we addressed whether oral administration of ginsenoside-Rb2 and -Rg3 is able to protect against rotavirus (RV) infection. The protective effect of ginsenosides against RV infection was examined using an in vivo experiment model in which newborn mice (10-dayold) were inoculated perorally (p.o.) with 1.5 × 106 plaque-forming units/mouse of RV strain SA11. When various dosages of ginsenoside-Rb2 (25-250 mg/kg) were administered 3days, 2 days, or 1 day before virus challenge, treatment with this ginsenoside at the dosage of 75 mg/kg 3days before virus infection most effectively reduced RV-induced diarrhea. In addition, consecutive administration of ginsenoside-Rb2 (75 mg/kg) at 3 days, 2 days, and 1 day before virus infection was more effective than single administration on day -3. The consecutive administration of ginsenoside-Rb2 also reduced virus titers in the bowels of RVinfected mice. In an experiment to compare the protective activity between ginsenoside-Rb2 and its two hydrolytic products (20(S)- and 20(R)-ginsenoside-Rg3), 20(S)-ginsenoside-Rg3, but not 20(R)-ginsenoside-Rg3, prevented RV infection. These results suggest that ginsenoside-Rb2 and its hydrolytic product, 20(S)-ginsenoside-Rg3, are promising candidates as an antiviral agent to protect against RV infection.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Desselberger U / 2014 / Rotaviruses / Virus Res. 190:75~96
Parashar UD / 2009 / Global mortality associated with rotavirus disease among children in 2004 / J. Infect. Dis. 200:S9~S15
Jiang V / 2010 / Performance of rotavirus vaccines in developed and developing countries / Hum. Vaccin. 6:532~542
Song X / 2009 / Adjuvant activities of saponins from traditional Chinese medicinal herbs / Vaccine 27:4883~4890
Sun HK / 2009 / Advances in saponin-based adjuvants / Vaccine 13:1787~1796
Parashar UD / 2009 / Global mortality associated with rotavirus disease among children in 2004 / J. Infect. Dis. 200:S9~S15
Jiang V / 2010 / Performance of rotavirus vaccines in developed and developing countries / Hum. Vaccin. 6:532~542
Song X / 2009 / Adjuvant activities of saponins from traditional Chinese medicinal herbs / Vaccine 27:4883~4890
Sun HK / 2009 / Advances in saponin-based adjuvants / Vaccine 13:1787~1796
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