지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제12호
- 발행연도
- 2015.1
- 수록면
- 1,997 - 2,006 (10page)
이용수
초록· 키워드
오류제보하기
Ginsenoside Rg3 is a bioactive ginseng constituent that has been reported to have diverse pathological and physiological effects, including anti-inflammatory and anti-metastatic activities. Metastasis is one of the most important factors involved in patients with melanoma. However, the molecular mechanism underlying the anti-metastatic activities of Rg3 in malignant melanoma cancer has not been fully elucidated. In this study, we have evaluated that Rg3 effectively inhibits metastasis of B16F10 melanoma cancer cells. We found that Rg3 significantly suppresses the migration, invasion, wound healing, and colony-forming abilities of B16F10 cells in a dose-dependent manner. Mechanistically, we demonstrate that Rg3 suppresses B16F10 cell metastasis by inhibiting MMP-13 expression. These results indicate that Rg3 suppresses the metastasis of B16F10 mouse melanoma cancer cells via MMP-13 regulation. Importantly, MMP-13 downregulation may influence the migration and invasion capabilities of melanoma cells and has been correlated with melanoma progression. Therefore, Rg3 is a potential therapeutic candidate that could be used to treat patients with metastatic melanoma.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Boregowda RK / 2014 / RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion / Cancer Lett 348 : 61 ~ 70
Chalkiadaki G / 2011 / Heparin plays a key regulatory role via a p53/FAK-dependent signaling in melanoma cell adhesion and migration / IUBMB Life 63 : 109 ~ 119
Chen D / 2013 / 1,25-Dihydroxyvitamin D3 activates MMP13 gene expression in chondrocytes through p38 MARK pathway / Int. J. Biol. Sci 9 : 649 ~ 655
Chen Y / 2014 / Shikonin inhibits prostate cancer cells metastasis by reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways / Int. Immunophar
Chiang HM / 2015 / Fisetin ameliorated photodamage by suppressing the MAP kinase/MMP pathway and NF-kappaB pathways / J. Agric. Food Chem
Chalkiadaki G / 2011 / Heparin plays a key regulatory role via a p53/FAK-dependent signaling in melanoma cell adhesion and migration / IUBMB Life 63 : 109 ~ 119
Chen D / 2013 / 1,25-Dihydroxyvitamin D3 activates MMP13 gene expression in chondrocytes through p38 MARK pathway / Int. J. Biol. Sci 9 : 649 ~ 655
Chen Y / 2014 / Shikonin inhibits prostate cancer cells metastasis by reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways / Int. Immunophar
Chiang HM / 2015 / Fisetin ameliorated photodamage by suppressing the MAP kinase/MMP pathway and NF-kappaB pathways / J. Agric. Food Chem
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Intracellular Trafficking Modulation by Ginsenoside Rg3 Inhibits Brucella abortus Uptake and Intracellular Survival within RAW 264.7 Cells
Journal of Microbiology and Biotechnology
2017 .01
-
Red Ginseng Water Extract Aggravates Inflammation in Sebocytes and Outer Root Sheath Cells after Treatment with Lipopolysaccharide and Mice with Cutibacterium acnesinduced Inflammatory Nodules
대한의진균학회지
2023 .06
-
Protection of Skin Fibroblasts from Infrared-A-Induced Photo-Damage Using Ginsenoside Rg3(S)-Incorporated Soybean Lecithin Liposomes
Journal of Microbiology and Biotechnology
2023 .01
-
Highly Efficient Biotransformation of Notoginsenoside R1 into Ginsenoside Rg1 by Dictyoglomus thermophilum β -xylosidase Xln-DT
Journal of Microbiology and Biotechnology
2022 .04
-
Synthesis of Quercetin and Luteolin Derivatives with Cell Proliferation Inhibitory Activity and Toxicity in B16 Melanoma Cells
대한화학회지
2023 .06
-
Ginsenoside Rg1 Induces Autophagy in Colorectal Cancer through Inhibition of the Akt/mTOR/p70S6K Pathway
Journal of Microbiology and Biotechnology
2024 .04
-
Inhibitory Effect of Ginsenosides Rh1 and Rg2 on Oxidative Stress in LPS-Stimulated RAW 264.7 Cells
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2018 .12
-
Lactobacillus plantarum을 이용한 산양삼 추출물의 진세노사이드 Rg1 및 Rg5의 함량 증대
한국미생물·생명공학회지
2017 .01
-
Ginsenoside Rg4 enhances the inductive effects of human dermal papilla spheres on hair growth via the AKT/GSK-3β/β-catenin signaling pathway
Journal of Microbiology and Biotechnology
2021 .01
-
Overexpression of microRNA-612 Restrains the Growth, Invasion, and Tumorigenesis of Melanoma Cells by Targeting Espin
Molecules and Cells
2018 .02
-
Biosurfactant Production by Marine Actinomycetes Isolates Streptomyces althioticus RG3 and Streptomyces californicus RG8 as Promising Sources of Antimicrobial and Antifouling Effects
한국미생물·생명공학회지
2021 .09
-
Anti-cancer effects of lucidadiol against malignant melanoma cells
극지연구소 초록집
2022 .09
-
Correction: Inhibitory Effect of Ginsenosides Rh1 and Rg2 on Oxidative Stress in LPS-Stimulated RAW 264.7 Cells
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .06
-
Effect of pulsed high-power microwave radiation on the melanoma and fibroblast cells
한국진공학회 학술발표회초록집
2019 .08
-
Changes of Ginsenoside Compositions in Cultivated Wild Ginseng with Different Steaming Temperatures and Time
동아시아식생활학회지
2023 .10
-
Protective Effects against Brucella abortus 544 Infection in a Murine Macrophage Cell Line and in a Mouse Model via Treatment with Sirtuin 1 Activators Resveratrol, Piceatannol and Ginsenoside Rg3
Journal of Microbiology and Biotechnology
2023 .04
-
Regulator of G-Protein Signaling 4 (RGS4) Controls Morphine Reward by Glutamate Receptor Activation in the Nucleus Accumbens of Mouse Brain
Molecules and Cells
2018 .03
-
Influence of atmospheric pressure plasma on the melanogenesis in melanoma cells
한국진공학회 학술발표회초록집
2015 .08
-
Anti-metastatic Effect of Garlic Hexane Extract on Lung Metastasis Induced by Melanoma B16F10 Cells in Mice
생명과학회지
2016 .02
-
Profiling of chemically transformed ginsenosides by steaming conditions of white ginseng based on UHPLC-Q/TOF-MS
한국분석과학회 학술대회
2021 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0