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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제7호
- 발행연도
- 2018.1
- 수록면
- 1,105 - 1,111 (7page)
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The flavin-dependent monooxygenase Sam5 was previously reported to be a bifunctional hydroxylase with coumarate 3-hydroxylase and resveratrol 3’-hydroxylase activities. In this article, we showed the Sam5 enzyme has 3’-hydroxylation activities for methylated resveratrols (pinostilbene and pterostilbene), hydroxylated resveratrol (oxyresveratrol), and glycosylated resveratrol (piceid) as substrates. However, piceid, a glycone-type stilbene used as a substrate for bioconversion experiments with the Sam5 enzyme expressed in Escherichia coli, did not convert to the hydroxylated compound astringin, but it was converted by in vitro enzyme reactions. Finally, we report a novel catalytic activity of Sam5 monooxygenase for the synthesis of piceatannol derivatives, 3’-hydroxylated stilbene compounds. Development of this bioproduction method for the hydroxylation of stilbenes is challenging because of the difficulty in expressing P450-type hydroxylase in E. coli and regiospecific chemical synthesis.
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참고문헌 (26)
참고문헌 신청
Pandey BP / 2011 / Screening of bacterial cytochrome P450s responsible for regiospecific hydroxylation of (iso)flavonoids / Enzyme Microb. Technol. 48:386~392
Kim DH / 2009 / Generation of the human metabolite piceatannol from the anticancer-preventive agent resveratrol by bacterial cytochrome P450 BM3 / Drug Metab. Dispos. 37:932~936
Furuya T / 2014 / Regioselective synthesis of piceatannol from resveratrol: catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells / Tetrahedron Lett. 55:2853~2855
Lin Y / 2014 / Biotechnological production of plantspecific hydroxylated phenylpropanoids / Biotechnol. Bioeng. 111:1895~1899
Furuya T / 2016 / Biocatalytic synthesis of 3,4,5,3',5'-pentahydroxy-trans-stilbene from piceatannol by two-component flavin-dependent monooxygenase HpaBC / Biosci. Biotechnol. Biochem. 80:193~198
Kim DH / 2009 / Generation of the human metabolite piceatannol from the anticancer-preventive agent resveratrol by bacterial cytochrome P450 BM3 / Drug Metab. Dispos. 37:932~936
Furuya T / 2014 / Regioselective synthesis of piceatannol from resveratrol: catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells / Tetrahedron Lett. 55:2853~2855
Lin Y / 2014 / Biotechnological production of plantspecific hydroxylated phenylpropanoids / Biotechnol. Bioeng. 111:1895~1899
Furuya T / 2016 / Biocatalytic synthesis of 3,4,5,3',5'-pentahydroxy-trans-stilbene from piceatannol by two-component flavin-dependent monooxygenase HpaBC / Biosci. Biotechnol. Biochem. 80:193~198
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