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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제7호
- 발행연도
- 2018.1
- 수록면
- 1,086 - 1,093 (8page)
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Honokiol, a bioactive compound isolated from the cone and bark of Magnolia officinalis, has been shown to have various activities including inhibition of the growth of Candida albicans. We investigated the roles of the Hsp90-calcineurin pathway in the antifungal activity of honokiol. The pharmacologic tool was employed to evaluate the effects of Hsp90 and calcineurin in the antifungal activity of honokiol. We also evaluated the protective effects of the calcineurin inhibitor cyclosporin A (CsA) on honokiol-induced mitochondrial dysfunction by the fluorescence staining method. The Hsp90 inhibitor potentiated the antifungal activity of honokiol. A C. albicans strain with the calcineurin gene deleted displayed enhanced sensitivity to honokiol. However, co-treatment with calcineurin inhibitor CsA attenuated the cytotoxic activity of honokiol due to the protective effect on mitochondria. Our results provide insight into the action mechanism of honokiol.
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참고문헌 (28)
참고문헌 신청
Singh SD / 2009 / Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin / PLoS Pathog. 5:e1000532
O'Meara TR / 2016 / Mapping the Hsp90 genetic network reveals ergosterol biosynthesis and phosphatidylinositol-4-kinase signaling as core circuitry governing cellular stress / PLoS Genet. 12:e1006142
Shapiro RS / 2011 / Regulatory circuitry governing fungal development, drug resistance, and disease / Microbiol. Mol. Biol. Rev. 75:213~267
Cruz MC / 2002 / Calcineurin is essential for survival during membrane stress in Candida albicans / EMBO J. 21:546~559
Blankenship JR / 2003 / Calcineurin is essential for Candida albicans survival in serum and virulence / Eukaryot. Cell 2:422~430
O'Meara TR / 2016 / Mapping the Hsp90 genetic network reveals ergosterol biosynthesis and phosphatidylinositol-4-kinase signaling as core circuitry governing cellular stress / PLoS Genet. 12:e1006142
Shapiro RS / 2011 / Regulatory circuitry governing fungal development, drug resistance, and disease / Microbiol. Mol. Biol. Rev. 75:213~267
Cruz MC / 2002 / Calcineurin is essential for survival during membrane stress in Candida albicans / EMBO J. 21:546~559
Blankenship JR / 2003 / Calcineurin is essential for Candida albicans survival in serum and virulence / Eukaryot. Cell 2:422~430
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