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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제4호
- 발행연도
- 2019.1
- 수록면
- 538 - 547 (10page)
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The aim of the present study was to evaluate the effects of two well-known natural antioxidants, vitamin C (VC) and vitamin E (VE), on the antifungal activity of honokiol against Candida albicans. The broth microdilution method was employed to test the antifungal activities of honokiol with or without antioxidants in the medium against C. albicans strain. Intracellular reactive oxygen species and lipid peroxidation were determined by fluorescence staining assay. Mitochondrial dysfunction was assessed by detecting the mitochondrial DNA and the mitochondrial membrane potential. We observed that VC could significantly potentiate the antifungal activities of honokiol while VE reduced the effectiveness of honokiol against C. albicans. In addition, VC accelerated honokiol-induced mitochondrial dysfunction and inhibited glycolysis leading to a decrease in cellular ATP. However, VE could protect against mitochondrial membrane lipid peroxidation and rescue mitochondrial function after honokiol treatment. Our research provides new insight into the understanding of the action mechanism of honokiol and VC combination against C. albicans.
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참고문헌 (38)
참고문헌 신청
Ott M / 2007 / Mitochondria, oxidative stress and cell death / Apoptosis 12:913~922
Villanueva C / 2012 / Antioxidant-induced stress / Int. J. Mol. Sci 13:2091~2109
Ayer A / 2014 / Cellular redox homeostasis, reactive oxygen species and replicative ageing in Saccharomyces cerevisiae / FEMS Yeast Res 14:60~72
Traber MG / 2011 / Vitamins C and E : beneficial effects from a mechanistic perspective / Free Radic. Biol. Med 51:1000~1013
Buettner GR / 1986 / Ascorbate autoxidation in the presence of iron and copper chelates / Free Radic. Res. Commun 1:349~353
Villanueva C / 2012 / Antioxidant-induced stress / Int. J. Mol. Sci 13:2091~2109
Ayer A / 2014 / Cellular redox homeostasis, reactive oxygen species and replicative ageing in Saccharomyces cerevisiae / FEMS Yeast Res 14:60~72
Traber MG / 2011 / Vitamins C and E : beneficial effects from a mechanistic perspective / Free Radic. Biol. Med 51:1000~1013
Buettner GR / 1986 / Ascorbate autoxidation in the presence of iron and copper chelates / Free Radic. Res. Commun 1:349~353
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