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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제1호
- 발행연도
- 2017.1
- 수록면
- 36 - 42 (7page)
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In this work, we isolated a surface layer protein (SLP) from a Bacillus thuringiensis (Bt) strain to evaluate it cytotoxic effects against MDA-MB-231 human breast cancer cells. AP11 was selected from a g roup o f Bt s trains u sing SLP o lig onucleotides developed from Bacillus conserved regions. The AP11 strain was grown in Luria Bertani medium until the late exponential phase; an 86 kDa protein was extracted using 5 M LiCl and identified by liquid chromatography– tandem mass spectrometry. It corresponded to a multispecies SLP highly similar to previously described SLPs in Bt. The MDA-MB-231 breast cancer cells LC50 was obtained using 0.25 μg/ml of the isolated SLP. HaCat non-cancerous cells presented 90% survival using the same protein concentration. Our data suggest that SLP cytotoxicity against MDA-MB-231 could be induced by an interaction with the CDH11 cell membrane receptor.
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참고문헌 (27)
참고문헌 신청
Allievi, Mariana Claudia / 2011 / Metal Biosorption by Surface-Layer Proteins from Bacillus Species / Journal of Microbiology and Biotechnology 21 (2) : 147 ~ 153
Beveridge TJ / 1997 / Function of S-layers / FEMS Microbiol. Rev 20 : 99 ~ 149
Bravo A / 2007 / Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control / Toxicon 49 : 423 ~ 435
Bravo A / 2011 / Bacillus thuringiensis: a story of a successful bioinsecticide / Insect. Biochem. Mol. Biol 41 : 423 ~ 431
Bravo A / 2012 / Evolution of Bacillus thuringiensis Cry toxins insecticidal activity / Microb. Biotechnol 6 : 17 ~ 26
Beveridge TJ / 1997 / Function of S-layers / FEMS Microbiol. Rev 20 : 99 ~ 149
Bravo A / 2007 / Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control / Toxicon 49 : 423 ~ 435
Bravo A / 2011 / Bacillus thuringiensis: a story of a successful bioinsecticide / Insect. Biochem. Mol. Biol 41 : 423 ~ 431
Bravo A / 2012 / Evolution of Bacillus thuringiensis Cry toxins insecticidal activity / Microb. Biotechnol 6 : 17 ~ 26
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