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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 34 - 42 (9page)
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Apigenin, a common natural product that is found in many plants and vegetables, has been reported to have many biological activities, including antioxidative, anti-inflammatory, and anticancer effects. The triple- negative breast carcinoma cell line MDA-MB-231 is known to be highly invasive and resistant to chemotherapy. In this study, we investigated the anticancer effect of apigenin on human MDA-MB-231 cells. First, the cytotoxicity of apigenin toward MDA-MB-231 cells was analyzed by MTT assay. Then, the cell cycle and apoptotic effects of apigenin were examined, and the molecular mechanism underlying its anticancer activity was explored. Apigenin inhibited the growth of the cells in a dose-dependent manner, correlating with the cell cycle arrest at the G2-M phase as well as an increase of early apoptosis. The cell-cycle inhibitory effect was highly associated with the increased expression of p21 and decreased expression of CDK6, cyclin D1, and cyclin B1. The induction of apoptosis by apigenin was associated with the upregulated expression of cleaved PARP and cleaved caspase-3, -7, and -9.
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참고문헌 (36)
참고문헌 신청
Sorlie T / 2006 / Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer / Mol. Cancer Ther 5:2914~2918
van de Vijver MJ / 2009 / A gene-expression signature as a predictor of survival in breast cancer / N. Engl. J. Med 347:1999~2009
Hudis CA / 2011 / Triple-negative breast cancer: an unmet medical need / Oncologist 16(Suppl 1):1~11
Dent R / 2007 / Triple-negative breast cancer: clinical features and patterns of recurrence / Clin. Cancer Res 13:4429~4434
Papay ZE / 2017 / Study on the pulmonary delivery system of apigeninloaded albumin nanocarriers with antioxidant activity / J. Aerosol. Med. Pulm. Drug Deliv 30:274~288
van de Vijver MJ / 2009 / A gene-expression signature as a predictor of survival in breast cancer / N. Engl. J. Med 347:1999~2009
Hudis CA / 2011 / Triple-negative breast cancer: an unmet medical need / Oncologist 16(Suppl 1):1~11
Dent R / 2007 / Triple-negative breast cancer: clinical features and patterns of recurrence / Clin. Cancer Res 13:4429~4434
Papay ZE / 2017 / Study on the pulmonary delivery system of apigeninloaded albumin nanocarriers with antioxidant activity / J. Aerosol. Med. Pulm. Drug Deliv 30:274~288
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