개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제4호
- 발행연도
- 2017.1
- 수록면
- 785 - 790 (6page)
이용수
초록· 키워드
오류제보하기
Two piloquinone derivatives isolated from Streptomyces sp. CNQ-027 were tested for the inhibitory activities of two isoforms of monoamine oxidase (MAO), which catalyzes monoamine neurotransmitters. The piloquinone 4,7-dihydroxy-3-methyl-2-(4-methyl-1- oxopentyl)-6H-dibenzo[b,d]pyran-6-one (1) was found to be a highly potent inhibitor of human MAO-B, with an IC50 value of 1.21 μM; in addition, it was found to be highly effective against MAO-A, with an IC50 value of 6.47 μM. Compound 1 was selective, but not extremely so, for MAO-B compared with MAO-A, with a selectivity index value of 5.35. Compound 1,8- dihydroxy-2-methyl-3-(4-methyl-1-oxopentyl)-9,10-phenanthrenedione (2) was moderately effective for the inhibition of MAO-B (IC50 = 14.50 μM) but not for MAO-A (IC50 > 80 μM). There was no time-dependency in inhibition of MAO-A or -B by compound 1, and the MAO-A and -B activities were almost completely recovered in the dilution experiments with an excess amount of compound 1. Compound 1 showed competitive inhibition for MAO-A and -B, with Ki values of 0.573 and 0.248 μM, respectively. These results suggest that piloquinones from a microbial source could be potent reversible MAO inhibitors and may be useful lead compounds for developing MAO enzyme inhibitors to treat related disorders, such as depression, Parkinson’s disease, and Alzheimer’s disease.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Carradori S / 2014 / Selective MAO-B inhibitors: a lesson from natural products / Mol. Divers 18 : 219 ~ 243
Carradori S / 2016 / Inhibition of human monoamine oxidase: biological and molecular modeling studies on selected natural flavonoids / J. Agric. Food Chem 64 : 9004 ~ 9011
Chaurasiya ND / 2016 / Isolation of acacetin from Calea urticifolia with inhibitory properties against human monoamine oxidase-A and -B / J. Nat. Prod 79 : 2538 ~ 2544
Fajemiroye JO / 2016 / Treatment of anxiety and depression: medicinal plants in retrospect / Fundam. Clin. Pharmacol 30 : 198 ~ 215
Fenical W / 2006 / Developing a new resource for drug discovery: marine actinomycete bacteria / Nat. Chem. Biol 2 : 666 ~ 673
Carradori S / 2016 / Inhibition of human monoamine oxidase: biological and molecular modeling studies on selected natural flavonoids / J. Agric. Food Chem 64 : 9004 ~ 9011
Chaurasiya ND / 2016 / Isolation of acacetin from Calea urticifolia with inhibitory properties against human monoamine oxidase-A and -B / J. Nat. Prod 79 : 2538 ~ 2544
Fajemiroye JO / 2016 / Treatment of anxiety and depression: medicinal plants in retrospect / Fundam. Clin. Pharmacol 30 : 198 ~ 215
Fenical W / 2006 / Developing a new resource for drug discovery: marine actinomycete bacteria / Nat. Chem. Biol 2 : 666 ~ 673
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Potent Selective Inhibition of Monoamine Oxidase A by Alternariol Monomethyl Ether Isolated from Alternaria brassicae
Journal of Microbiology and Biotechnology
2017 .01
-
Inhibition of Monoamine Oxidase by Anithiactins from Streptomyces sp.
Journal of Microbiology and Biotechnology
2015 .01
-
Chromenone Derivatives as Monoamine Oxidase Inhibitors from Marine-Derived MAR4 Clade Streptomyces sp. CNQ-031
Journal of Microbiology and Biotechnology
2021 .01
-
Extract of Streptomyces sp. R301 as a Highly Potent Tyrosinase Inhibitor
한국미생물학회 학술대회논문집
2019 .04
-
Defect states in amorphous SiNx:H compounds
한국진공학회 학술발표회초록집
2016 .08
-
Identification of Vegetable-Derived Compounds as Potent Inhibitors of SARS-CoV-2 Main Protease: Implications for COVID-19 Therapeutics
한국분석과학회 학술대회
2023 .05
-
Phase transition and magnetic property of La(Fe,Si)13 compound
한국자기학회 학술연구발표회 논문개요집
2021 .11
-
Differences in dietary intakes, body compositions, and biochemical indices between metabolically healthy and metabolically abnormal obese Korean women
Nutrition Research and Practice
2019 .12
-
Differences in dietary intakes, body compositions, and biochemical indices between metabolically healthy and metabolically abnormal obese Korean women
Nutrition Research and Practice
2019 .12
-
Potent Anti-influenza Effects of Novel mPGES-1 Inhibitors Mediated by Inhibition of PI3K/AKT Signaling Pathway and Pro-inflammatory Gene Expression
한국미생물학회 학술대회논문집
2015 .04
-
Increased Fungal Infections while using Emerging Therapies (Biologics and Small-molecule Inhibitors) for Treating Skin Diseases: A Review
대한의진균학회지
2021 .09
-
식물 유용 방선균 2종의 배양 및 포자생성 최적화 조건 탐색
Research in Plant Disease(식물병연구)
2023 .06
-
Inhibition of Human Neutrophil Elastase by Sesquiterpene Lactone Dimers from the Flowers of Inula britannica
Journal of Microbiology and Biotechnology
2018 .01
-
오이 탄저병 방제에 효과적인 Streptomyces sp. S20-465 유래 대사물질 규명
Research in Plant Disease(식물병연구)
2024 .06
-
Aflatoxin B1 Detoxification by Aspergillus oryzae from Meju, a Traditional Korean Fermented Soybean Starter
Journal of Microbiology and Biotechnology
2017 .01
-
Discovery of Chitin Deacetylase Inhibitors through Structure-Based Virtual Screening and Biological Assays
Journal of Microbiology and Biotechnology
2022 .04
-
해양 방선균 유래 항 Methicillin Resistant Staphylococcus aureus 물질의 활성 및 상승 효과
한국해양바이오학회지
2022 .12
-
Isolation and Characterization of Antimicrobial Compounds Produced from Streptomyces spp.
한국미생물학회 학술대회논문집
2015 .04
-
Antifungal Substances from Streptomyces sp. A3265 Antagonistic to Plant Pathogenic Fungi
Mycobiology
2015 .01
-
Development of Antifungal Compounds from Streptomyces sp. NF186 against Fusarium oxysporum f. sp. conglutinans
한국미생물학회 학술대회논문집
2016 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0