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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제4호
- 발행연도
- 2017.1
- 수록면
- 709 - 717 (9page)
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초록· 키워드
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Mucosal tissues are the initial site through which most pathogens invade. As such, vaccines and adjuvants that modulate mucosal immune functions have emerged as important agents for disease prevention. Herein, we investigated the immunomodulatory mechanisms of the B subunit of Escherichia coli heat-labile enterotoxin type IIa (LT-IIa-B5), a potent non-toxic mucosal adjuvant. Alternations in gene expression in response to LT-IIa-B5 were identified using a genome-wide transcriptional microarray that focused on dendritic cells (DC), a type of cell that broadly orchestrates adaptive and innate immune responses. We found that LT-IIa-B5 enhanced the homing capacity of DC into the lymph nodes and selectively regulated transcription of pro-inflammatory cytokines, chemokines, and cytokine receptors. These data are consistent with a model in which directional activation and differentiation of immune cells by LT-IIa-B5 serve as a critical mechanism whereby this potent adjuvant amplifies mucosal immunity to co-administered antigens.
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참고문헌 (19)
참고문헌 신청
Boberg A / 2008 / Enhancement of epitope-specific cellular immune responses by immunization with HIV-1 peptides genetically conjugated to the B-subunit of recombinant cholera
Commins SP. / 2015 / Mechanisms of oral tolerance / Pediatr. Clin. North Am 62 : 1523 ~ 1529
Gouwy M / 2011 / CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection / Eur. J. Immunol 41 : 963 ~
Harrod T / 2001 / Long-term persistence and recall of immune responses in aged mice after mucosal immunization / Oral Microbiol. Immunol 16 : 170 ~ 177
Holmgren J / 2005 / Mucosal immunity and vaccines / Nat. Med 11 : S45 ~ S53
Commins SP. / 2015 / Mechanisms of oral tolerance / Pediatr. Clin. North Am 62 : 1523 ~ 1529
Gouwy M / 2011 / CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection / Eur. J. Immunol 41 : 963 ~
Harrod T / 2001 / Long-term persistence and recall of immune responses in aged mice after mucosal immunization / Oral Microbiol. Immunol 16 : 170 ~ 177
Holmgren J / 2005 / Mucosal immunity and vaccines / Nat. Med 11 : S45 ~ S53
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