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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 318 - 327 (10page)
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CD4+ T helper (Th) cells play a crucial role in the modulation of innate and adaptive immune responses through the differentiation of Th precursor cells into several subsets, including Th1, Th2, Th17, and regulatory T (Treg) cells. Effector Th and Treg cells are distinguished by the production of signature cytokines and are important for eliminating intracellular and extracellular pathogens and maintaining immune homeostasis. Stimulation of naive Th cells by T cell receptor and specific cytokines activates master transcription factors and induces lineage specification during the differentiation of Th cells. The master transcription factors directly activate the transcription of signature cytokine genes and also undergo post-translational modifications to fine-tune cytokine production and maintain immune balance through cross-regulation with each other. This review highlights the post-translational modifications of master transcription factors that control the differentiation of effector Th and Treg cells and provides additional insights on the immune regulation mediated by protein argininemodifying enzymes in effector Th cells.
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참고문헌 (103)
참고문헌 신청
Asano, M. / 1996 / Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation / J. Exp. Med 184:387~396
Barber, K. W. / 2018 / The ABCs of PTMs / Nat. Chem. Biol. 14:188~192
Beier, U. H. / 2011 / Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells / Curr. Opin. Immunol 23:670~678
Bennett, C. L. / 2000 / X-Linked syndrome of polyendocrinopathy, immune dysfunction, and diarrhea maps to Xp11.23-Xq13.3 / Am. J. Hum. Genet 66:461~468
Bettelli, E. / 2005 / Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells / Proc. Natl. Acad. Sci. U. S. A 102:5138~5143
Barber, K. W. / 2018 / The ABCs of PTMs / Nat. Chem. Biol. 14:188~192
Beier, U. H. / 2011 / Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells / Curr. Opin. Immunol 23:670~678
Bennett, C. L. / 2000 / X-Linked syndrome of polyendocrinopathy, immune dysfunction, and diarrhea maps to Xp11.23-Xq13.3 / Am. J. Hum. Genet 66:461~468
Bettelli, E. / 2005 / Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells / Proc. Natl. Acad. Sci. U. S. A 102:5138~5143
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