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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 123 - 129 (7page)
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ObjectiveNuclear factor kappa-B (NF-кB) is a critical proinflammatory regulator that has been suggested to play a pivotal role in the pathogenesis and pathophysiology of endometriosis. In the present study, we aimed to evaluate whether the expression of NF-кB p65 subunit is increased in the eutopic endometrium and/or in the adenomyosis nodule of women with adenomyosis.
MethodsThirty-three women with histologically confirmed adenomyosis after laparoscopic or transabdominal hysterectomy were recruited. Women with carcinoma in situ of uterine cervix without evidence of adenomyosis or endometriosis (n=32) served as controls. Formalin-fixed, paraffin-embedded archival tissues were sectioned and immunostained utilizing a monoclonal anti-human NF-кB p65 subunit antibody, and the immunoreactivity of NF-кB p65 subunit was compared between women with and without adenomyosis.
ResultsThe immunoreactivities of both the nuclear and the cytoplasmic NF-кB p65 subunit were significantly increased in the stromal cells in the eutopic endometrium as well as in the adenomyosis nodule of women with adenomyosis compared with controls, respectively. The nuclear expression of NF-кB p65 subunit was significantly higher in the glandular cells in the eutopic endometrium as well as the adenomyosis nodule of women with adenomyosis compared with controls, respectively.
ConclusionThe expression of NF-кB p65 is increased in the eutopic endometrium and adenomyosis nodule of women with adenomyosis, which strongly suggest that NF-кB plays a critical role in the pathogenesis and/or pathophysiology of adenomyosis.
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참고문헌 (24)
참고문헌 신청
Bergeron C / 2006 / Pathology and physiopathology of adenomyosis / Best Pract Res Clin Obstet Gynaecol 20:511~521
Farquhar C / 2006 / Medical and surgical management of adenomyosis / Best Pract Res Clin Obstet Gynaecol 20:603~616
McElin TW / 1974 / Adenomyosis of the uterus / Obstet Gynecol Annu 3:425~441
Curtis KM / 2002 / Disruption of the endometrial-myometrial border during pregnancy as a risk factor for adenomyosis / Am J Obstet Gynecol 187:543~544
Kitawaki J / 1997 / Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium / Biol Reprod 57:514~519
Farquhar C / 2006 / Medical and surgical management of adenomyosis / Best Pract Res Clin Obstet Gynaecol 20:603~616
McElin TW / 1974 / Adenomyosis of the uterus / Obstet Gynecol Annu 3:425~441
Curtis KM / 2002 / Disruption of the endometrial-myometrial border during pregnancy as a risk factor for adenomyosis / Am J Obstet Gynecol 187:543~544
Kitawaki J / 1997 / Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium / Biol Reprod 57:514~519
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