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논문 기본 정보

자료유형
학술저널
저자정보
Garima Yadav (All India Institute of Medical Sciences) Meenakshi Rao (All India Institute of Medical Sciences) Meenakshi Gothwal (All India Institute of Medical Sciences) Pratibha Singh (All India Institute of Medical Sciences) Priyanka Kathuria (All India Institute of Medical Sciences) Prem Prakash Sharma (All India Institute of Medical Sciences)
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제64권 제5호
발행연도
2021.9
수록면
454 - 461 (8page)

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ObjectiveThe primary objective of this study was to establish the presence of nerve fibers in the eutopic endometrium ofwomen with endometriosis and to determine whether these nerve fibers are exclusive to endometriosis or are alsofound in other pelvic pathologies associated with dysmenorrhea. MethodsEndometrial tissue was obtained by aspiration (Pipelle), endometrial curettage, or following hysterectomy inwomen with endometriosis confirmed through histopathological examination, leiomyomas, and adenomyosis. Theeutopic endometrium was subjected to immunohistochemical staining to detect PGP 9.5, which is a highly specificpan-neuronal marker. The nerve fiber density was correlated with the patient’s pain score, as indicated by the VisualAnalog Scale. A control group was formed by staining the endometrium of women presenting with dysmenorrheabut without the above-mentioned disorders. ResultsNerve fibers were observed in sections of the endo-myometrium (in the deep endometrium) in 68% of patients withendometriosis who underwent hysterectomy or a deep endometrial biopsy. Nerve fibers were not observed in theaspirated endometrium of women with endometriosis. Only 13.7% of women with adenomyosis and 3.3% of womenwith fibroids had nerve fibers in their endometrium. Nerve fiber density was correlated with pain score in womenwith endometriosis. ConclusionNerve fibers were found in the functional layer of eutopic endometrium in women with endometriosis; hence, weconcluded that the presence of nerve fibers in the eutopic endometrium could diagnose endometriosis with a fairlygood specificity of 92.7%. However, the absence of nerve fibers does not always exclude the disease.

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