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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 669 - 674 (6page)
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초록· 키워드
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ObjectiveThis study aimed to develop a nomogram that predicts ongoing pregnancy after in vitro fertilization and embryotransfer (IVF-ET) using patient age and serum hormonal markers. MethodsA total of 284 IVF-ET cycles were retrospectively analyzed. At 14 days post-oocyte pick-up (OPU), the serum humanchorionic gonadotropin (HCG) and progesterone levels were measured. The main predicted outcome was ongoingpregnancy. ResultsPatient age and serum of HCG and progesterone levels at 14 days post-OPU were good predictors of ongoingpregnancy. The cut-off value and area under the curve (AUC) (95% confidence interval) were 36.5 years and 0.666(0.599–0.733), respectively, for patient age; 67.8 mIU/mL and 0.969 (0.951–0.987), respectively, for serum HCG level;and 29.8 ng/mL and 0.883 (0.840–0.925), respectively, for serum progesterone level. When the prediction model wasconstructed using these three parameters, the addition of serum progesterone level to the prediction model didnot increase its overall predictability. Furthermore, a high linear co-relationship was found between serum HCG andprogesterone levels. Therefore, we developed a new nomogram using patient age and HCG serum level only. TheAUC of the newly developed nomogram for predicting ongoing pregnancy after IVF-ET cycles using patient age andserum HCG level was as high as 0.975. ConclusionWe showed that ongoing pregnancy may be predicted using only patient age and HCG serum level. Our nomogramcould help clinicians and patients predict ongoing pregnancy after IVF-ET if the serum JCG level was ≥5 IU/L at 14 dayspost-OPU.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Turner K / 2013 / Stress and anxiety scores in first and repeat IVF cycles: a pilot study / PLoS One 8:e63743
Jee Hyun Kim / 2012 / Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET / Clinical and Experimental Reproductive Medicine 39(1):28~32
Wang Q / 2017 / Serum human chorionic gonadotropin measured 7 days following day 3 embryo transfer might predict pregnancy outcome in IVF / Gynecol Endocrinol 33:62~66
Urbancsek J / 2002 / Serum human chorionic gonadotropin measurements may predict pregnancy outcome and multiple gestation after in vitro fertilization / Fertil Steril 78:540~542
van Mello NM / 2012 / Diagnostic value of serum hCG on the outcome of pregnancy of unknown location: a systematic review and meta-analysis / Hum Reprod Update 18:603~617
Jee Hyun Kim / 2012 / Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET / Clinical and Experimental Reproductive Medicine 39(1):28~32
Wang Q / 2017 / Serum human chorionic gonadotropin measured 7 days following day 3 embryo transfer might predict pregnancy outcome in IVF / Gynecol Endocrinol 33:62~66
Urbancsek J / 2002 / Serum human chorionic gonadotropin measurements may predict pregnancy outcome and multiple gestation after in vitro fertilization / Fertil Steril 78:540~542
van Mello NM / 2012 / Diagnostic value of serum hCG on the outcome of pregnancy of unknown location: a systematic review and meta-analysis / Hum Reprod Update 18:603~617
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