지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 401 - 406 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard referencevalue and to compare them with patients who subsequently developed preeclampsia (PE).
Materials and Methods: In this prospective study, 117 healthy singleton pregnancies were enrolled between 6 to 20 weeks of gestationat 2 participating medical centers during October 2010 to March 2012. Urine and serum samples were collected at the time of enrollment, each trimester, and at 4 to 6 weeks postpartum. Enzyme-linked immunosorbent assay for nephrin was performed and samples from patients who subsequently developed PE were compared to the normal patients.
Results: Of 117 patients initially enrolled, 99 patients delivered at the study centers and of those patients, 12 (12.1%) developed PE at a median gestational age of 34+4 weeks (range 29+5–36+6). In the normal patients (n=68), serum nephrin level decreased and urinarynephrin level increased during the latter of pregnancy. In 12 patients who subsequently developed PE, a significant rise in the 3rd trimester serum and urinary nephrin levels, compared to the controls, was observed (p<0.001), and this increase occurred 9 days prior to the onset of clinical disease.
Conclusion: As the onset of PE was preceded by the rise in the serum and urinary nephrin in comparison to normal pregnancy, serum and urinary nephrin may be a useful predictive marker of PE.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Myatt L / 2012 / First-trimester prediction of preeclampsia in nulliparous women at low risk / Obstet Gynecol 119:1234~1242
Myers JE / 2013 / Angiogenic factors combined with clinical risk factors to predict preterm pre-eclampsia in nulliparous women: a predictive test accuracy study / BJOG 120:1215~1223
Myers JE / 2013 / Integrated proteomics pipeline yields novel biomarkers for predicting preeclampsia / Hypertension 61:1281~1288
Roberts JM / 2001 / Pathogenesis and genetics of pre-eclampsia / Lancet 357:53~56
Aita K / 2009 / Acute and transient podocyte loss and proteinuria in preeclampsia / Nephron Clin Pract 112 : c65 ~ c70
Myers JE / 2013 / Angiogenic factors combined with clinical risk factors to predict preterm pre-eclampsia in nulliparous women: a predictive test accuracy study / BJOG 120:1215~1223
Myers JE / 2013 / Integrated proteomics pipeline yields novel biomarkers for predicting preeclampsia / Hypertension 61:1281~1288
Roberts JM / 2001 / Pathogenesis and genetics of pre-eclampsia / Lancet 357:53~56
Aita K / 2009 / Acute and transient podocyte loss and proteinuria in preeclampsia / Nephron Clin Pract 112 : c65 ~ c70
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Serum adipocytokines and adiposity as predictive indices of preeclampsia
Clinical Hypertension
2021 .01
-
Differences in clinical presentation and pregnancy outcomes in antepartum preeclampsia and new-onset postpartum preeclampsia: Are these the same disorder?
Obstetrics & Gynecology Science
2016 .01
-
Role of ultrasound in the evaluation of first-trimester pregnancies in the acute setting
ULTRASONOGRAPHY
2020 .01
-
New cut-off point for D-dimer in the diagnosis of pulmonary embolism during pregnancy
Blood Research
2021 .09
-
고위험 임신의 외래 산전진찰시 고려사항
Perinatology
2023 .06
-
Stabilization of serum alkaline phosphatase in hemodialysis patients by implementation of local chronic kidney disease-mineral bone disorder management strategy: A quality improvement study
Kidney Research and Clinical Practice
2018 .01
-
Non-alcoholic fatty liver disease in pregnancy, paving the way for adverse pregnancy outcome risk assessment
Clinical and Molecular Hepatology
2022 .01
-
Blood level of adipokines and nutritional status variables in adolescent pregnancy
Obstetrics & Gynecology Science
2020 .01
-
Effect of Early Plasma Exchange on Survival in Patients with Severe Fever with Thrombocytopenia Syndrome: A Multicenter Study
Yonsei Medical Journal
2017 .07
-
초임부의 임신경험과 임신 중 체중변화에 대한 태도와의 관계
Women's Health Nursing
2019 .01
-
Is preeclampsia itself a risk factor for the development of metabolic syndrome after delivery?
Obstetrics & Gynecology Science
2019 .01
-
Development of a novel nomogram for predicting ongoing pregnancy after in vitro fertilization and embryo transfer
Obstetrics & Gynecology Science
2018 .01
-
Is there any Potential Clinical Impact of Serum Phosphorus and Magnesium in Patients with Lung Cancer at First Diagnosis? A Multi-institutional Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The association of reproductive hormones, thyroid function, and vitamin levels with premature ejaculation: A prospective case-control study
Investigative and Clinical Urology
2024 .03
-
Elevated Alanine Aminotransferase in Early Pregnancy and Subsequent Development of Gestational Diabetes and Preeclampsia
Journal of Korean Medical Science
2020 .01
-
Differential Expression of NME4 in Trophoblast Stem-Like Cells and Peripheral Blood Mononuclear Cells of Normal Pregnancy and Preeclampsia
Journal of Korean Medical Science
2023 .04
-
Effects of Serum 25-hydroxy-vitamin D and Fetal Bone Growth during Pregnancy
대한골대사학회지
2015 .01
-
Therapeutic outcomes of methotrexate injection in unruptured interstitial pregnancy
Obstetrics & Gynecology Science
2017 .01
-
Association Between Individual Air Pollution (PM 10 , PM 2.5 ) Exposure and Adverse Pregnancy Outcomes in Korea: A Multicenter Prospective Cohort, Air Pollution on Pregnancy Outcome (APPO) Study
Journal of Korean Medical Science
2024 .04
-
A study to compare maternal and perinatal outcome in early vs. late onset preeclampsia
Obstetrics & Gynecology Science
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0