지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 112 - 116 (5page)
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초록· 키워드
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Objective The hereditary nonpolyposis colorectal cancer is inherited syndrome characterized by the development of cancers in various organ system; these includes colorectum, endometrium, and less frequently, small bowel, stomach, urinary tract, ovaries, and brain. We aimed to investigate the clinicopathologic characteristics of hereditary nonpolyposis colorectal cancer patients who had both endometrial and colorectal cancers.
Methods Between January 2004 and December 2013, 12 women diagnosed with endometrial and colorectal cancers in a single institution were included in this analysis. For these patients, clinical and molecular findings were analyzed retrospectively.
Results All 12 women undertook microsatellite instability analysis, and 9 (75%) were confirmed of having microsatellite instability-high. Among 9 cases with immunohistochemical staining for MLH1 and MSH2, 6 were positive for the loss of mismatch repair protein. Mutational analyses for MLH1 and MSH2 were performed in 3 out of 12 patients; all of them showed germline mutation.
Conclusion This study suggests that there is a genetic background in patients with double primary malignancies in their endometrium and colorectum when analyzed with microsatellite instability studies, immunohistochemistry staining, and mutation studies. This finding supports the necessity of re-defining the high-risk groups in endometrial cancers clinically. This will also help diagnose malignancies in such patients in early stages, as well as counsel other family members.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Aarnio M. / 1999 / Cancer risk in mutation carriers of DNA-mismatch-repair genes / Int J Cancer 81 : 214 ~ 218
Banno K. / 2004 / Association of HNPCC and endometrial cancers / Int J Clin Oncol 9 : 262 ~ 269
Boland CR. / 2008 / The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome : from bench to bedside / F
Hewitson TD. / 2010 / Tissue preparation for histochemistry : fixation, embedding, and antigen retrieval for light microscopy / Methods Mol Biol 611 : 3 ~ 18
Lim MC. / 2010 / Hereditary non-polyposis colorectal cancer/Lynch syndrome in Korean patients with endometrial cancer / Jpn J Clin Oncol 40 : 1121 ~ 1127
Banno K. / 2004 / Association of HNPCC and endometrial cancers / Int J Clin Oncol 9 : 262 ~ 269
Boland CR. / 2008 / The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome : from bench to bedside / F
Hewitson TD. / 2010 / Tissue preparation for histochemistry : fixation, embedding, and antigen retrieval for light microscopy / Methods Mol Biol 611 : 3 ~ 18
Lim MC. / 2010 / Hereditary non-polyposis colorectal cancer/Lynch syndrome in Korean patients with endometrial cancer / Jpn J Clin Oncol 40 : 1121 ~ 1127
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