지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 605 - 611 (7page)
이용수
초록· 키워드
오류제보하기
Purpose The Korean Hereditary Tumor Registry, the first and one of the largest registries of hereditary tumors in Korea, has registered about 500 families with hereditary cancer syndromes. This study evaluates the temporal changes in clinicopathologic features and surgical patterns of Lynch syndrome (LS) patients.
Materials and Methods Data on 182 unrelated LS patients were collected retrospectively. The patients were divided into the period 1 group (registered in 1990-2004) and 2 (registered in 2005-2014). The clinical characteristics of the two groups were compared to identify changes over time.
Results The period 1 group included 76 patients; the period 2 group, 106 patients. The mean ages at diagnosis were 45.1 years (range, 13 to 85 years) for group 1 and 49.7 years (range, 20 to 84 years) for group 2 (p=0.015). The TNM stage at diagnosis did not differ significantly— period 1 group: stage 0-I (n=18, 23.7%), II (n=37, 48.7%), III (n=19, 25.0%), and IV (n=2, 2.6%); period 2 group: stage 0-I (n=30, 28.3%), II (n=35, 33.0%), III (n=37, 34.9%), and IV (n=4, 3.8%). Extended resection was more frequently performed (55/76, 72.4%) in the period 1 group than period 2 (49/106, 46.2%) (p=0.001).
Conclusion Colorectal cancer in patients with LS registered at the Korean Hereditary Tumor Registry is still diagnosed at an advanced stage, more than two decades after registry’s establishment.
Segmental resection was more frequently performed in the past decade. A prompt nationwide effort to raise public awareness of hereditary colorectal cancer and to support hereditary cancer registries is required in Korea.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Aaltonen LA / 1998 / Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease / N Engl J Med 338:1481~1487
Vasen HF / 2007 / Guidelines for the clinical management of Lynch syndrome(hereditary non-polyposis cancer) / J Med Genet 44:353~362
Lynch HT / 2003 / Hereditary colorectal cancer / N Engl J Med 348:919~932
Vasen HF / 1999 / New clinical criteria for hereditary nonpolyposis colorectal cancer(HNPCC, Lynch syndrome)proposed by the International Collaborative group on HNPCC / Gastroenterology 116:1453~1456
Umar A / 2004 / Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer(Lynch syndrome)and microsatellite instability / J Natl Cancer Inst 96:261~268
Vasen HF / 2007 / Guidelines for the clinical management of Lynch syndrome(hereditary non-polyposis cancer) / J Med Genet 44:353~362
Lynch HT / 2003 / Hereditary colorectal cancer / N Engl J Med 348:919~932
Vasen HF / 1999 / New clinical criteria for hereditary nonpolyposis colorectal cancer(HNPCC, Lynch syndrome)proposed by the International Collaborative group on HNPCC / Gastroenterology 116:1453~1456
Umar A / 2004 / Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer(Lynch syndrome)and microsatellite instability / J Natl Cancer Inst 96:261~268
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Screening and surveillance for hereditary colorectal cancer
Intestinal research
2024 .04
-
Genetic Testing and Management of Hereditary Colorectal Cancer
대한임상종양학회 학술대회지
2015 .02
-
Hereditary cancer panel and clinical application
대한외과학회 학술대회 초록집
2016 .11
-
Genetic Approach and Management of Hereditary Breast Cancer
대한외과학회 학술대회 초록집
2019 .10
-
Hereditary Cancer of Thyroid Gland
대한임상종양학회 학술대회지
2015 .02
-
Characteristics of hereditary nonpolyposis colorectal cancer patients with double primary cancers in endometrium and colorectum
Obstetrics & Gynecology Science
2015 .01
-
Universal Screening for Lynch Syndrome Compared with Pedigree-Based Screening: 10-Year Experience in a Tertiary Hospital
Cancer Research and Treatment
2023 .01
-
Observation Study: Clinical significance and adequate management of the multiple primary cancers accompanied with hereditary and sporadic colorectal cancer
대한외과학회 학술대회 초록집
2017 .11
-
Incidence of Recurrence Colon Polyp of Patients with Multiple Polyposis Who Underwent Surgery for Colorectal Cancer Stage I-III Not Diagnosed as Hereditary Syndromes
대한외과학회 학술대회 초록집
2020 .11
-
Hereditary Breast and Ovarian Cancer Syndrome (HBOC) : Support for One`s Medical Choice
대한임상종양학회 학술대회지
2015 .02
-
Cancer Registration in India - Current Scenario and Future Perspectives
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Genetics of hereditary nephrotic syndrome: a clinical review
Clinical and Experimental Pediatrics
2017 .01
-
Medullary thyroid carcinoma : a 30-year experience at one institution in Korea
Annals of Surgical Treatment and Research
2016 .12
-
Analysis of Hereditary Nonpolyposis Colorectal Cancer in Malay Cohorts using Immunohistochemical Screening
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Familial Pancreatic Cancer and the Future of Directed Screening
Gut and Liver
2017 .01
-
발생위험도에 따른 대장암 선별전략
대한의사협회지
2017 .01
-
Genotypic and Phenotypic Characteristics of Hereditary Colorectal Cancer
Annals of Coloproctology
2021 .12
-
Establishment of a registry of clinical data and bioresources for rare nervous system diseases
Osong Public Health and Research Persptectives
2024 .04
-
Korea Central Cancer Registry : Limitations of statistics and research of individual cancers
대한외과학회 학술대회 초록집
2016 .11
-
Muir-Torre variant of Hereditary Non-polyposis Colorectal Cancer
대한외과학회 학술대회 초록집
2019 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0