지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 379 - 387 (9page)
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초록· 키워드
오류제보하기
ObjectiveThe goal of this study was to evaluate the etiologies and clinical outcomes of Korean recurrent pregnancy loss (RPL) patients. And also, we investigated the differences between primary and secondary RPL patients, between two and three or more pregnancy losses.
MethodsOne hundred seventy eight women diagnosed as RPL were enrolled. We performed chromosomal analysis, thyroid stimulating hormone, prolactin, blood glucose, plasminogen activator inhibitor-1, natural killer cell proportion, anticardiolipin antibodies, antiphospholipid antibodies, lupus anticoagulant, anti-β2glycoprotein-1 antibodies, antinuclear antibody, protein C, protein S, antithrombin III, homocysteine, MTFHR gene, factor V Leiden mutation, and hysterosalphingography/hysteroscopic evaluation.
ResultsThe mean age was 34.03±4.30 years, and mean number of miscarriages was 2.69±1.11 (range, 2 to 11). Anatomical cause (13.5%), chromosomal abnormalities (5.6%), and endocrine disorders (34.3%) were observed in RPL women. Elevated natural killer cell and antiphospholipid antibodies were observed in 43.3% and 7.3% each. Among of 178 women, 77 women were pregnant. After management of those women, live birth rate was 84.4% and mean gestational weeks was 37.63±5.12. Women with three or more RPL compared with women with two RPL had more common anatomical cause such as intrauterine adhesions and lower rates of spontaneous pregnancy. Compare with secondary RPL women, immunological abnormalities were more common in primary RPL. However, miscarriage rates were not different.
ConclusionImmunological factor including autoimmune and alloimmune disorders was most common etiology of RPL. Inherited thrombophilia showed different patterns with other ethnic countries. Miscarriage rates were not different between primary and secondary RPL, or between two and three or more miscarriages group.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Jaslow CR / 2010 / Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses / Fertil Steril 93:1234~1243
Practice Committee of American Society for Reproductive Medicine / 2013 / Definitions of infertility and recurrent pregnancy loss: a committee opinion / Fertil Steril 99:63
Gao H / 2015 / Prothrombin G20210A mutation is associated with recurrent pregnancy loss : a systematic review and meta-analysis update / Thromb Res 135:339~346
Ford HB / 2009 / Recurrent pregnancy loss: etiology, diagnosis, and therapy / Rev Obstet Gynecol 2:76~83
Sergi C / 2015 / Factor V Leiden mutation in women with early recurrent pregnancy loss : a metaanalysis and systematic review of the causal association / Arch Gynecol Obstet 291:671~679
Practice Committee of American Society for Reproductive Medicine / 2013 / Definitions of infertility and recurrent pregnancy loss: a committee opinion / Fertil Steril 99:63
Gao H / 2015 / Prothrombin G20210A mutation is associated with recurrent pregnancy loss : a systematic review and meta-analysis update / Thromb Res 135:339~346
Ford HB / 2009 / Recurrent pregnancy loss: etiology, diagnosis, and therapy / Rev Obstet Gynecol 2:76~83
Sergi C / 2015 / Factor V Leiden mutation in women with early recurrent pregnancy loss : a metaanalysis and systematic review of the causal association / Arch Gynecol Obstet 291:671~679
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