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자료유형
학술저널
저자정보
저널정보
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제30권 제2호
발행연도
2016.1
수록면
114 - 120 (7page)

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Purpose: To determine the effects of intravitreal anti-vascular endothelial growth factor (VEGF) on thickness ofthe retinal nerve fiber layer (RNFL) in patients with age-related macular degeneration. Methods: Twenty eyes of 20 patients diagnosed with age-related macular degeneration who underwent intravitrealanti-VEGF injection were studied. Postinjection RNFL thickness was measured using optical coherencetomography. Average thickness, four-quadrant RNFL thicknesses, and intraocular pressure (IOP) in affectedeyes were measured before and 6 and 12 months after anti-VEGF injection for comparison. RNFL thicknessand IOP in affected and normal fellow eyes were also compared. Given that macular lesions can affect RNFLthickness, the changes in thickness were evaluated by dividing the 12 clock-hour RNFL into the pathologic areasadjacent to the lesion and the non-pathologic area. Results: The mean clock-hour segment in the pathologic area was 4.8 hours. A significantly thicker RNFL wasexhibited in temporal quadrants and pathologic areas (p = 0.043 and 0.048, respectively) in affected eyesbefore injection compared to the baseline RNFL thickness in normal eyes. No significant differences werefound in RNFL thickness or IOP between affected and normal eyes after injection. The changes over time inthe temporal and pathologic areas were statistically significant at 6 and 12 months after injection compared tobaseline data (p < 0.05). No significant differences were displayed in RNFL thickness in the other three quadrantsor in non-pathologic areas in either affected or normal eyes. Sequential changes in RNFL thickness inaffected eyes were not significant. Conclusions: Repeat intravitreal anti-VEGF treatment did not have a significant effect on RNFL thickness. RNFL thickness significantly decreased with time in the pathologic areas and in the temporal segment adjacentto exudative macular lesions. The reduction in RNFL thickness was most likely associated with changesin the macular lesion rather than with anti-VEGF injection.

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