지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 269 - 278 (10page)
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초록· 키워드
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Background: Although reactive oxygen species (ROS) have been produced in both mouse bone marrow-derived dendritic cells (DCs) and XS-106 DCs by contact sensitizers and irritants in previous studies, the generation of ROS in human monocyte-derived DCs (MoDCs) and their role in contact hypersensitivity (CHS) has yet to be elucidated.
Objective: The purpose of this study was to determine whether contact allergens and irritants induce ROS in MoDCs and, if so, to evaluate the role of contact allergen and irritant induced-ROS in MoDCs in CHS. Methods:Production of ROS was measured by 5-(and-6)-chloromethyl-2’,7’-dichlorodihydrofluorescein diacetate (CMH2DCFDA)assay. Surface CD86 and HLA-DR molecules were detected by flow cytometry. Protein carbonylation was detected by Western blotting. Results: ROS were produced by contact allergens such as dinitrochlorobenzene (DNCB)and thimerosal and the irritant benzalkonium chloride (BKC). DNCB-induced, but not BKC-induced, ROS increased surface CD86 and HLA-DR molecules on MoDCs and induced protein carbonylation. These changes were reduced in the presence of antioxidant N-acetyl cysteine.
Conclusion: Our results suggest that DNCB-induced ROS may be different from those induced by irritant BKC. The DNCB-induced ROS may be associated with the CHS response, because they activate surface molecules on DCs that are important for generating immune reactions.
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참고문헌 (26)
참고문헌 신청
Armstrong JS / 2007 / Measurement of reactive oxygen species in cells and mitochondria / Methods Cell Biol 80 : 355 ~ 377
Banchereau J / 1998 / Dendritic cells and the control of immunity / Nature 392 : 245 ~ 252
Banchereau J / 2000 / Immunobiology of dendritic cells / Annu Rev Immunol 18 : 767 ~ 811
Bartosz G / 2009 / Reactive oxygen species:destroyers or messengers? / Biochem Pharmacol 77 : 1303 ~ 1315
Bickers DR / 2006 / Oxidative stress in the pathogenesis of skin disease / J Invest Dermatol 126 : 2565 ~ 2575
Banchereau J / 1998 / Dendritic cells and the control of immunity / Nature 392 : 245 ~ 252
Banchereau J / 2000 / Immunobiology of dendritic cells / Annu Rev Immunol 18 : 767 ~ 811
Bartosz G / 2009 / Reactive oxygen species:destroyers or messengers? / Biochem Pharmacol 77 : 1303 ~ 1315
Bickers DR / 2006 / Oxidative stress in the pathogenesis of skin disease / J Invest Dermatol 126 : 2565 ~ 2575
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