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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 54 - 63 (10page)
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Background: While the beneficial effects of topical epidermal growth factor (EGF) on wound healing have been repeatedly reported, there are few reports about the effects of EGF on inflammatory skin diseases including acne. Objective: To clarify the effects of EGF on acne, it was investigated whether recombinant human EGF (rhEGF) signalling can affect Propionibacterium acnes-induced cytokine expression in human epidermal keratinocytes. Methods: The cultured normal human epidermal keratinocytes (NHK) were co-treated with P. acnes and rhEGF, and mRNA levels of interleukin (IL)-1α, IL-8 and tumor necrosis factor (TNF)-α; toll-like receptor 2 (TLR2); and nuclear factor kappa B (NF-κB) were determined. Specific enzyme-linked immunosorbent assay kits were used to measure the IL-1α, IL-8 and TLR2 expression as well as the NF-κB activation in P. acnes and rhEGF-treated NHK. After infecting the cultured NHK with live P. acnes, an increased expression of IL-1α, IL-8 and TNF-α was detected, which was prevented by rhEGF co-treatment. Results: TLR2 and NF-κB activity increased after P. acnes treatment, and rhEGF treatment decreased TLR2 expression and NF-κB activity dose-dependently. The inhibition of EGF receptor by gefitinib attenuated the inhibitory effect of rhEGF on these increased expressions of proinflammatory cytokines and TLR2 and activity of NF-κB in NHK stimulated by P. acnes. Conclusion: These results suggest that EGF attenuated P. acnes -induced inflammatory responses, at least in part, through the modulation of TLR2 signalling, and the topical application of rhEGF may be beneficial to relieve the inflammatory reactions of acne.
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참고문헌 (37)
참고문헌 신청
McInturff JE / 2005 / The role of toll-like receptors in the pathogenesis and treatment of dermatological disease / J Invest Dermatol 125:1~8
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124:783~801
Shibata M / 2009 / Glucocorticoids enhance Toll-like receptor 2 expression in human keratinocytes stimulated with Propionibacterium acnes or proinflammatory cytokines / J Invest Dermatol 129:375~382
Li ZJ / 2014 / Propionibacterium acnes activates the NLRP3 inflammasome in human sebocytes / J Invest Dermatol 134:2747~2756
Dispenza MC / 2012 / Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients / J Invest Dermatol 132:2198~2205
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124:783~801
Shibata M / 2009 / Glucocorticoids enhance Toll-like receptor 2 expression in human keratinocytes stimulated with Propionibacterium acnes or proinflammatory cytokines / J Invest Dermatol 129:375~382
Li ZJ / 2014 / Propionibacterium acnes activates the NLRP3 inflammasome in human sebocytes / J Invest Dermatol 134:2747~2756
Dispenza MC / 2012 / Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients / J Invest Dermatol 132:2198~2205
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