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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 688 - 698 (11page)
이용수
초록· 키워드
오류제보하기
Background: Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA). Here, we explore a possible mechanism by which a lipid receptor, G2A, regulates immune responses to a commensal bacterium. Objective: To elucidate the inflammatory properties of G2A in monocytes in response to PA stimulation. Furthermore, our study sought to investigate pathways by which lipids modulate immune responses in response to PA. Methods: Our studies focused on monocytes collected from human peripheral blood mononuclear cells, the monocytic cell line THP-1, and a lab strain of PA. Our studies involved the use of enzyme-linked immunosorbent, Western blot, reverse transcription polymerase chain reaction, small interfering RNA (siRNA), and microarray analysis of human acne lesions in the measurements of inflammatory markers. Results: G2A gene expression is higher in acne lesions compared to normal skin and is inducible by the acne therapeutic, 13-cis -retinoic acid. In vitro, PA induces both the Toll-like receptor 2-dependent expression of G2A as well as the production of the G2A ligand, 9-hydroxyoctadecadienoic acid, from human monocytes. G2A gene knockdown through siRNA enhances PA stimulation of interleukin (IL)-6, IL-8, and IL-1β possibly through increased activation of the ERK1/2 MAP kinase and nuclear factor kappa B p65 pathways. Conclusion: G2A may play a role in quelling inflammatory cytokine response to PA, revealing G2A as a potential attenuator of inflammatory response in a disease associated with a commensal bacterium.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bolick DT / 2007 / Absence of the G protein-coupled receptor G2A in mice promotes monocyte/endothelial interactions in aorta / Circ Res 100 : 572 ~ 580
Chalker DK / 1987 / Efficacy of topical isotretinoin 0.05% gel in acne vulgaris: results of a multicenter, double-blind investigation / J Am Acad Dermatol 17 : 251 ~ 254
Choi CW / 2013 / Facial sebum affects the development of acne, especially the distribution of inflammatory acne / J Eur Acad Dermatol Venereol 27 : 301 ~ 306
Cohen LJ / 2015 / Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist / Proc Natl Acad Sci U
Dispenza MC / 2012 / Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients / J Invest Dermatol 132 : 2198 ~ 2205
Chalker DK / 1987 / Efficacy of topical isotretinoin 0.05% gel in acne vulgaris: results of a multicenter, double-blind investigation / J Am Acad Dermatol 17 : 251 ~ 254
Choi CW / 2013 / Facial sebum affects the development of acne, especially the distribution of inflammatory acne / J Eur Acad Dermatol Venereol 27 : 301 ~ 306
Cohen LJ / 2015 / Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist / Proc Natl Acad Sci U
Dispenza MC / 2012 / Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients / J Invest Dermatol 132 : 2198 ~ 2205
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