지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 409 - 416 (8page)
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초록· 키워드
오류제보하기
Background: Atopic dermatitis (AD) is related to a deficiency of delta-6-desaturase, an enzyme responsible for converting linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) as a source of GLA has been of interest in the management of AD. Objective: The aim of this randomized, double-blinded, placebo-controlled clinical study is to evaluate the efficacy and safety of EPO in Korean patients with AD. Methods: Fifty mild AD patients with an Eczema Area Severity Index (EASI) score of 10 or less were enrolled and randomly divided into two groups. The first group received an oval unmarked capsule containing 450 mg of EPO (40 mg of GLA) per capsule, while placebo capsules identical in appearance and containing 450 mg of soybean oil were given to the other group. Treatment continued for a period of four months. EASI scores, transepidermal water loss (TEWL), and skin hydration were evaluated in all the AD patients at the baseline, and in months 1, 2, 3, and 4 of the study. Results: At the end of month 4, the patients of the EPO group showed a significant improvement in the EASI score (p=0.040), whereas the patients of the placebo group did not. There was a significant difference in the EASI score between the EPO and placebo groups (p=0.010). Although not statistically significant, the TEWL and skin hydration also slightly improved in the EPO patients group. Conclusion: We suggest that EPO is a safe and effective medicine for Korean patients with mild AD.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Thomas Bieber / 2010 / Atopic Dermatitis / Annals of Dermatology 22(2):125~137
Cork MJ / 2009 / Epidermal barrier dysfunction in atopic dermatitis / J Invest Dermatol 129:1892~1908
McPherson T / 2016 / Current Understanding in Pathogenesis of Atopic Dermatitis / Indian J Dermatol 61:649~655
Horrobin DF / 2000 / Essential fatty acid metabolism and its modification in atopic eczema / Am J Clin Nutr 71(1 Suppl):367S~372S
Wright S / 1991 / Essential fatty acids and the skin / Br J Dermatol 125:503~515
Cork MJ / 2009 / Epidermal barrier dysfunction in atopic dermatitis / J Invest Dermatol 129:1892~1908
McPherson T / 2016 / Current Understanding in Pathogenesis of Atopic Dermatitis / Indian J Dermatol 61:649~655
Horrobin DF / 2000 / Essential fatty acid metabolism and its modification in atopic eczema / Am J Clin Nutr 71(1 Suppl):367S~372S
Wright S / 1991 / Essential fatty acids and the skin / Br J Dermatol 125:503~515
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