Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children

Cheon, Bo Ram; Shin, Jeong Eun; Kim, Yun Ji; Shim, Jae Won; Kim, Deok Soo; Jung, Hye Lim; Park, Moon Soo; Shim, Jung Yeon

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저자정보: Cheon, Bo Ram (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) Shin, Jeong Eun (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) Kim, Yun Ji (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) Shim, Jae Won (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) Kim, Deok Soo (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) Jung, Hye Lim (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) Park, Moon Soo (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) Shim, Jung Yeon (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine)

저널정보: 대한소아청소년과학회 Korean journal of pediatrics Korean journal of pediatrics 제58권 제3호

발행연도: 2015.1

수록면: 96 - 101 (6page)

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Purpose: Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. Methods: We enrolled 91 children with AD and 32 control subjects without history or symptoms of allergic diseases. Blood was drawn to evaluate complete blood cell count, total eosinophil count (TEC), and total IgE, specific IgE to common allergens, 25(OH)D, and IL-31 levels. Serum 25(OH)D and IL-31 levels were measured using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. The scoring atopic dermatitis (SCORAD) index was used to evaluate the severity of AD. Results: The mean 25(OH)D level was significantly lower in the AD group than in the control group; 25(OH)D decreased greatly in the moderate and severe AD groups compared with the mild AD group. Children with atopic sensitization showed significantly lower 25(OH)D levels than nonatopic children. However, serum IL-31 levels were not related to AD group, SCORAD index, or 25(OH)D levels. The SCORAD index was inversely correlated with serum 25(OH)D level and positively correlated with TECs and total IgE levels. Children with moderate and severe AD had significantly higher TECs than children with mild AD. Conclusion: Vitamin D is related to the severity of AD independently of IL-31.

#Atopic dermatitis #25-hydroxyvitamin D #Atopic sensitization #Interleukin-31 #Child

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