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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 688 - 693 (6page)
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초록· 키워드
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Background: There are few pharmacologic options to reduce erythema and flushing in patients with recalcitrant erythematotelangiectatic rosacea (ETR). We previously reported two cases of refractory flushing and erythema of rosacea that were successfully treated with intradermal botulinum toxin injection, and additional research is needed to prove the efficacy and safety of this treatment. Objective: To report the efficacy and safety of botulinum toxin injection as an aid in persistent erythema of rosacea patients. Methods: A total of 20 Korean patients with recalcitrant ETR were enrolled to receive treatment by injection of botulinum toxin. Patients received one treatment of intradermal botulinum toxin injection and were assessed 1, 2, 4, and 8 weeks after treatment. The severity of erythema and telangiectasia was investigated by a non-treating physician, and the Erythema Index (EI) was assessed by mexameter at each visit. Patient satisfaction and any adverse events were also assessed at each visit. Results: 17 patients completed all follow-up visits and were included in the analysis. Intradermal injection of botulinum toxin significantly reduced erythema severity and EI in ETR patients. Patients reported a satisfaction score of 2.94±0.56 at 8 weeks after treatment. Except for three patients who discontinued the study early due to inconvenience of facial muscle paralysis, 17 patients participating in the final analysis did not report side effects except injection pain at the time of the procedure. Conclusion: Intradermal injection of botulinum toxin can be used as an effective and relatively safe adjuvant agent for recalcitrant and persistent erythema of ETR patients.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Schwab VD / 2011 / Neurovascular and neuroimmune aspects in the pathophysiology of rosacea / J Investig Dermatol Symp Proc 15:53~62
Dayan SH / 2012 / A new treatment regimen for rosacea: onabotulinumtoxinA / J Drugs Dermatol 11:e76~e79
Bloom BS / 2015 / Impact of intradermal abobotulinumtoxinA on facial erythema of rosacea / Dermatol Surg 41(Suppl 1):S9~S16
Shah AR / 2008 / Use of intradermal botulinum toxin to reduce sebum production and facial pore size / J Drugs Dermatol 7:847~850
Oh YJ / 2011 / A split-face study using botulinum toxin type B to decrease facial erythema index / J Cosmet Laser Ther 13:243~248
Dayan SH / 2012 / A new treatment regimen for rosacea: onabotulinumtoxinA / J Drugs Dermatol 11:e76~e79
Bloom BS / 2015 / Impact of intradermal abobotulinumtoxinA on facial erythema of rosacea / Dermatol Surg 41(Suppl 1):S9~S16
Shah AR / 2008 / Use of intradermal botulinum toxin to reduce sebum production and facial pore size / J Drugs Dermatol 7:847~850
Oh YJ / 2011 / A split-face study using botulinum toxin type B to decrease facial erythema index / J Cosmet Laser Ther 13:243~248
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