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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 529 - 535 (7page)
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초록· 키워드
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Background: Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine.
TPMT genotyping is widely used for screening of AZA-related toxicity during routine clinical practice in Korea. However, the data of TPMT genotypes and its AZA-related toxicity have not been studied in the field of dermatology. Objective: The aim of this study was to evaluate the genetic basis of TPMT polymorphism in Korean dermatologic patients and subsequently to investigate the relationship between mutant TPMT and adverse responses to AZA treatment. Methods: This study was retrospective, single- center study. One hundred forty-nine Korean dermatologic patients who underwent TPMT screening test were included. Each patient’s medical records, the result of TPMT screening test, dose and treatment period of AZA, and side effects, were reviewed. Laboratory tests were assessed at each visit in order to monitor adverse drug reactions. Leukopenia grading was used in accordance with the common terminology criteria for adverse events (CTCAE) ver. 4.03. Results: Behçet’s disease was the leading disorder among the patients. The frequency of TPMT mutation was 4.0% (6/149) among the participants in this study. Four of the six patients with genetic alterations were treated with a low-dose AZA regimen, but no AZA-related adverse events were observed.
Conclusion: Our results suggest that 1) TPMT polymorphisms in Korean dermatologic patients are similar to those previously reported in Asian patients with the most common mutant allele being TPMT*3C and 2) AZA can be used in the patients with these polymorphisms under a careful dosing regimen.
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참고문헌 (22)
참고문헌 신청
Appell ML / 2013 / Nomenclature for alleles of the thiopurine methyltransferase gene / Pharmacogenet Genomics 23 : 242 ~ 248
Cao Q / 2009 / Thiopurine methyltransferase gene polymorphisms in Chinese patients with inflammatory bowel disease / Digestion 79 : 58 ~ 63
Dubinsky MC / 2000 / Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease / Gastroenterology 118 : 705 ~ 713
Gisbert JP / 2008 / Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review / Am J Gastroenterol 103 : 1783 ~ 1800
Hibi T / 2006 / Novel pathophysiological concepts of inflammatory bowel disease / J Gastroenterol 41 : 10 ~ 16
Cao Q / 2009 / Thiopurine methyltransferase gene polymorphisms in Chinese patients with inflammatory bowel disease / Digestion 79 : 58 ~ 63
Dubinsky MC / 2000 / Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease / Gastroenterology 118 : 705 ~ 713
Gisbert JP / 2008 / Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review / Am J Gastroenterol 103 : 1783 ~ 1800
Hibi T / 2006 / Novel pathophysiological concepts of inflammatory bowel disease / J Gastroenterol 41 : 10 ~ 16
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