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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 328 - 337 (10page)
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초록· 키워드
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Background/Aims: Recent genome-wide analyses have provided strong evidence concerning adverse events caused bythiopurine drugs such as azathioprine (AZA) and 6-mercaptopurine. The strong associations identified between NUDT15p.Arg139Cys and thiopurine-induced leukopenia and severe hair loss have been studied and confirmed over the last 2 years. However, other coding variants, including NUDT15 p.Val18_Val19insGlyVal, NUDT15 p.Val18Ile, and FTO p.Ala134Thr, and anoncoding variation in RUNX1 (rs2834826) remain to be examined in detail in this respect. Therefore, we investigated the correlationbetween these adverse events and the 5 recently identified variants mentioned above among Japanese patients withinflammatory bowel diseases (IBD). Methods: One hundred sixty thiopurine-treated patients with IBD were enrolled. Genotypingwas performed using TaqMan SNP Genotyping Assays or Sanger sequencing. Results: None of the 5 variants were associatedwith gastrointestinal intolerance to AZA. However, NUDT15 p.Arg139Cys was significantly associated with the intervalbetween initiation and discontinuation of AZA among patients with gastrointestinal intolerance. This variant was stronglyassociated with early (<8 weeks) and late (≥8 weeks) leukopenia and severe hair loss. Moreover, it correlated with the intervalbetween initiation of thiopurine therapy and leukopenia occurrence, and average thiopurine dose. NUDT15 p.Val18_Val19insGlyVal,NUDT15 p.Val18Ile, FTO p.Ala134Thr, and RUNX1 rs2834826 exhibited no significant relationship with the adverseevents examined. Conclusions: Of the 5 variants investigated, NUDT15 p.Arg139Cys had the strongest impact on thiopurineinducedleukopenia and severe hair loss; therefore, its genotyping should be prioritized over that of other variants in efforts topredict these adverse events in Japanese patients with IBD.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Satoshi Yamada / 2015 / Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis / Intestinal research 13(3):250~258
Takuya Yoshino / 2015 / Efficacy of Thiopurines in Biologic-Naive Japanese Patients With Crohn’s Disease: A Single-Center Experience / Intestinal research 13(3):266~273
Roberts RL / 2015 / Update on thiopurine pharmacogenetics in inflammatory bowel disease / Pharmacogenomics 16:891~903
Takatsu N / 2009 / Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease / J Gastroenterol Hepatol 24:1258~1264
이강문 / 2015 / Use of Thiopurines in Inflammatory Bowel Disease: A Consensus Statement by the Korean Association for the Study of Intestinal Diseases (KASID) / Intestinal research 13(3):193~207
Takuya Yoshino / 2015 / Efficacy of Thiopurines in Biologic-Naive Japanese Patients With Crohn’s Disease: A Single-Center Experience / Intestinal research 13(3):266~273
Roberts RL / 2015 / Update on thiopurine pharmacogenetics in inflammatory bowel disease / Pharmacogenomics 16:891~903
Takatsu N / 2009 / Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease / J Gastroenterol Hepatol 24:1258~1264
이강문 / 2015 / Use of Thiopurines in Inflammatory Bowel Disease: A Consensus Statement by the Korean Association for the Study of Intestinal Diseases (KASID) / Intestinal research 13(3):193~207
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