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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 142 - 151 (10page)
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초록· 키워드
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Background: We developed an ethanol extract of peanutsprouts (EPS), a peanut sprout-derived natural product,which contains a high level of trans-resveratrol (176.75 μg/ml)and was shown to have potent antioxidant activity. Objective:We evaluated the potential anti-inflammatory activity of EPSby measuring its antioxidant potential in skin. Methods: Theanti-inflammatory activity of EPS was tested using two modelsof skin inflammation: oxazolone (OX)-induced contact dermatitisin mice and compound 48/80-treated HaCaT cells. Asbiomarkers of skin inflammation, cyclooxygenase-2 (COX-2)and nerve growth factor (NGF) levels were measured.
Results: OX-induced contact dermatitis was suppressedmarkedly in mice that were treated with an ointment containing5% EPS as evidenced by a decrease in the extent of scalingand thickening (p＜0.05) and supported by a histologicalstudy. COX-2 (messenger RNA [mRNA] and protein) andNGF (mRNA) levels, which were upregulated in the skin ofOX-treated mice, were suppressed markedly in the skin ofOX＋EPS-treated mice. Consistent with this, compound48/80-induced expression of COX-2 (mRNA and protein)and NGF (mRNA) in HaCaT cells were suppressed by EPStreatment in a dose-dependent manner. As an inhibitor ofNF-κB, IκB protein levels were dose-dependently upregulatedby EPS. Fluorescence-activated cell sorting (FACS) analysisrevealed that EPS scavenged compound 48/80-inducedreactive oxygen species (ROS) in HaCaT cells. Conclusion:EPS exerts a potent anti-inflammatory activity via its antioxidantactivity in both mouse skin and compound48/80-treated HaCaT cells in vitro. Compound 48/80-treatedHaCaT cells are a useful new in vitro model of skininflammation.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Albers KM /
Anggakusuma, Yanti / 2010 / Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells / J D
Aridor M / 1993 / Activation of exocytosis by the heterotrimeric G protein Gi3 / Science 262 : 1569 ~ 1572
Aubdool AA / 2011 / Neurovascular aspects of skin neurogenic inflammation / J Investig Dermatol Symp Proc 15 : 33 ~ 39
Baur JA / 2006 / Therapeutic potential of resveratrol:the in vivo evidence / Nat Rev Drug Discov 5 : 493 ~ 506
Anggakusuma, Yanti / 2010 / Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells / J D
Aridor M / 1993 / Activation of exocytosis by the heterotrimeric G protein Gi3 / Science 262 : 1569 ~ 1572
Aubdool AA / 2011 / Neurovascular aspects of skin neurogenic inflammation / J Investig Dermatol Symp Proc 15 : 33 ~ 39
Baur JA / 2006 / Therapeutic potential of resveratrol:the in vivo evidence / Nat Rev Drug Discov 5 : 493 ~ 506
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