지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 291 - 297 (7page)
이용수
초록· 키워드
오류제보하기
Background: Behçet’s disease (BD), first described in 1937 as a triadic complex of symptoms (oral aphthae, genital ulcers, and hypopyon uveitis), is a chronic, relapsing, multisystemic idiopathic inflammatory disease. Objective: The objective of this study was to investigate the usability of messenger RNA (mRNA) expression of cytokine genes for following up patients with BD and also assess polymorphisms in these genes as to how they influence mRNA expression. Methods: This study investigated the role of the IL1A −889(C/T), IL1B − 511(C/T), and IL2 −330(T/G) polymorphisms by polymerase chain reaction (PCR)-restriction fragment length polymorphisms and the expression levels of the genes by real- time PCR in BD. Results: The frequency of the IL2 −330 G allele was found to be significantly higher in patients with BD. A decreased level of IL1A gene expression was found in the patient group with clinically active BD compared to controls. Increased IL1B gene expression levels werefound in patient groups with active, inactive, or ocular BD (p<0.001). IL2 gene expression level manifested no significant change compared to controls in the patient group with clinically active BD; it increased in the groups with clinically inactive BD or ocular involvement. Conclusion: IL1A, IL1B, and IL2 gene expression, and IL2 promoter polymorphisms, may be valuable markers for predicting risk in the development of BD. We believe that the results reveal the importance of achieving a better understanding of BD and the prospects of developing future therapeutic strategies.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Akman A / 2008 / Relationship between periodontal findings and the TNF-alpha Gene 1031T/C polymorphism in Turkish patients with Behcet's disease / J Eur Acad Dermatol Venere
Alayli G / 2007 / T helper 1 type cytokines polymorphisms: association with susceptibility to Behcet's disease / Clin Rheumatol 26 : 1299 ~ 1305
Colgecen E / 2015 / The prevalence of Behcet's disease in a city in Central Anatolia in Turkey / Int J Dermatol 54 : 286 ~ 289
Coskun M / 2005 / Specific interleukin-1 gene polymorphisms in Turkish patients with Behcet's disease / Exp Dermatol 14 : 124 ~ 129
Duzgun N / 2005 / Cytokine inhibitors: soluble tumor necrosis factor receptor 1 and interleukin-1 receptor antagonist in Behcet's disease / Rheumatol Int 25 : 1 ~ 5
Alayli G / 2007 / T helper 1 type cytokines polymorphisms: association with susceptibility to Behcet's disease / Clin Rheumatol 26 : 1299 ~ 1305
Colgecen E / 2015 / The prevalence of Behcet's disease in a city in Central Anatolia in Turkey / Int J Dermatol 54 : 286 ~ 289
Coskun M / 2005 / Specific interleukin-1 gene polymorphisms in Turkish patients with Behcet's disease / Exp Dermatol 14 : 124 ~ 129
Duzgun N / 2005 / Cytokine inhibitors: soluble tumor necrosis factor receptor 1 and interleukin-1 receptor antagonist in Behcet's disease / Rheumatol Int 25 : 1 ~ 5
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