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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 674 - 680 (7page)
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초록· 키워드
오류제보하기
Objective: Circadian rhythms have been linked to psychiatric disorders such as Depression and Bipolar Disorder (BD). Given previous evidences of sleep/circadian disturbances as well as the genetic susceptibility for BD, we decided to investigate the possible link between the PERIOD3 (Per3) circadian gene and BD.
Methods: This is a genetic association case (BD) vs. control study of the Per3 gene. We further subdivided our BD sample into “good sleepers” (PSQI ≤5) and “poor sleepers” (PSQI>5) according to the Pittsburgh Sleep Quality Index (PSQI) global score, and then we assessed genetic association of the Per3 gene with sleep quality in the BD group.
Results: There were 209 cases and 213 controls in our sample. The GT genotype of the SNP rs707467 significantly associated with BD (χ2=8.80; p-value=0.01; adjusted residual=±2.6). We also found significant association of the SNP rs10462020 allele T with BD (χ2=5.81; p-value=0.01) as well as the genotype TT (χ2= 6.01; p-value=0.04; adjusted residual=±2.4).
Conclusion: In this study we demonstrated evidences of genetic association between the Per3 gene and BD. The results of association between the Per3 gene and BD in our sample may bring additional evidence to the former findings of association between the Per3 gene and BD.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Aschoff J / 1984 / Circadian timing / Ann N Y Acad Sci 423 : 442 ~ 468
Atkinson M / 1975 / Autorhytmometry in manic-depressives / Chronobiologia 2 : 325 ~ 335
Benedetti F / 2008 / A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder / Neurosci Lett 445 : 184 ~ 187
Cajochen C / 2003 / Role of melatonin in the regulation of human circadian rhythms and sleep / J Neuroendocrinol 15 : 432 ~ 437
Cichon S / 2001 / A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q / Hum Mol Genet 10 : 2933 ~ 2944
Atkinson M / 1975 / Autorhytmometry in manic-depressives / Chronobiologia 2 : 325 ~ 335
Benedetti F / 2008 / A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder / Neurosci Lett 445 : 184 ~ 187
Cajochen C / 2003 / Role of melatonin in the regulation of human circadian rhythms and sleep / J Neuroendocrinol 15 : 432 ~ 437
Cichon S / 2001 / A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q / Hum Mol Genet 10 : 2933 ~ 2944
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